A New Microfluidic Phase-Transfer Reaction Using HPLC Guard Columns as the Reactor for the N3-Protection of Uridine Derivatives
A New Microfluidic Phase-Transfer Reaction Using HPLC Guard Columns as the Reactor for the N3-Protection of Uridine Derivatives
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使用 HPLC 保护柱作为尿苷衍生物 N3 保护反应器的新型微流体相转移反应
DOI：
10.1055/s-0035-1560264
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发表时间：
2015
期刊：
影响因子：
2
通讯作者：
Mitsuo Sekine
中科院分区：
文献类型：
--
作者：
Nobuhiro Tago;Yoshiaki Masaki;Hiroshi Nagasawa;Takashi Kanamori;Akihiro Ohkubo;Kohji Seio;Mitsuo Sekine
采用一种新型的微流控装置，以高效液相色谱仪为反应器，研究了尿苷衍生物与酰氯的N3-酰化反应。酰化产物在几秒钟的非常短的反应时间内以超过80%的产率获得。
N3-Acylation of uridine derivatives with acyl chlorides, mediated by a phase-transfer reaction, was studied using a new microfluidic device containing an HPLC guard as an effective reactor. The acylated products were obtained in more than 80% yields in very short reaction times of several seconds.