Interplay of neuronal processes during response inhibition: Results from a combined event-related potentials (ERPs)/transcranial magnetic stimulation (TMS) study on methylphenidate
Interplay of neuronal processes during response inhibition: Results from a combined event-related potentials (ERPs)/transcranial magnetic stimulation (TMS) study on methylphenidate
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DOI：
10.1016/j.ijpsycho.2011.05.004
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发表时间：
2011-08-01
影响因子：
3
通讯作者：
Kratz, Oliver
中科院分区：
文献类型：
--
作者：
Hoegl, Thomas;Heinrich, Hartmut;Kratz, Oliver
通常使用事件相关电位（ERP）或应用经颅磁刺激（TMS）来研究运动系统中的兴奋和抑制过程，以研究反应抑制的神经元过程。我们进行了一个更精细的分析反应抑制相结合的方法，其目的是确定ERPs和TMS parameters.During一个去/不去任务之间的相互作用，运动系统的兴奋性进行了测量，使用TMS单，双脉冲和脑电活动记录在健康成人（n = 14）。每个参与者完成两次测试，一次是安慰剂，一次是哌甲酯（双盲，交叉设计）。研究哌醋甲酯的作用作为这种组合方法的示例应用。开发回归模型，抑制相关的TMS测量（例如，短的皮质内抑制）和伴随的负变化解释了MPH和安慰剂药物下Nogo-P3的约85%的方差。运动系统的抑制效应越小，需要越多的终末反应控制，分配给抑制过程的评价资源也越多，P3越大。因此，运动系统（皮层）的加工与控制加工之间可能存在相互作用，其来源可能在前额叶皮层和前扣带皮层（ACC），虽然ERP更确切地代表抑制过程和反应控制的启动和监测，但运动抑制可以使用TMS进行最佳分析。结合ERP/TMS分析可以允许开发不同的模型，涉及反应抑制过程的相互作用。(C)2011爱思唯尔有限公司版权所有。
The neuronal processes underlying response inhibition are often studied using either event-related potentials (ERPs) or by applying transcranial magnetic stimulation (TMS) to investigate excitatory and inhibitory processes in the motor system. We performed a more refined analysis of response inhibition by combining both approaches with the aim of identifying an interplay between ERPs and TMS parameters.During a go/nogo task, motor system excitability was measured using TMS single and double pulses and brain electrical activity was recorded in healthy adults (n = 14). Each participant completed two testing sessions, once on placebo and once on methylphenidate (double-blind, crossover design). Studying the effects of methylphenidate served as an example application for this combined approach.Developing regression models, inhibition-related TMS measures (e.g., short intracortical inhibition) and the contingent negative variation explained about 85% of the variance of the nogo-P3 under both MPH and placebo medication. The smaller the inhibitory effect in the motor system, the more terminal response control was required and the more resources were allocated for the evaluation of the inhibitory process, respectively, as indicated by a larger P3.Thus, an interplay between processes in the motor system (cortex) and control processes with sources in the prefrontal cortex and the anterior cingulate cortex (ACC) may take place, acting complementarily to facilitate a correct nogo-response.While ERPs rather represent initiation and monitoring of inhibitory processes and response control, motor inhibition may be best analyzed using TMS. A combined ERP/TMS analysis may allow for the development of distinct models concerning the interplay of processes involved in response inhibition. (C) 2011 Elsevier B.V. All rights reserved.