Association of Intracranial Aneurysms With Aortic Aneurysms in 125 Patients With Fusiform and 4253 Patients With Saccular Intracranial Aneurysms and Their Family Members and Population Controls
Association of Intracranial Aneurysms With Aortic Aneurysms in 125 Patients With Fusiform and 4253 Patients With Saccular Intracranial Aneurysms and Their Family Members and Population Controls
复制标题
DOI：
10.1161/jaha.119.013277
复制
发表时间：
2019-09-17
影响因子：
5.4
通讯作者：
Lindgren, Antti E.
中科院分区：
文献类型：
--
作者：
Kurtelius, Arttu;Vantti, Nelli;Lindgren, Antti E.
背景-颅内动脉瘤（IA）和主动脉瘤（AA）并存的程度不同。我们试图比较梭形颅内动脉瘤（fIA）和囊状颅内动脉瘤（sIA）疾病中AA的风险，并评价fIA疾病和AA之间可能的遗传联系。此外，特征和动脉瘤的fIA和sIA patients.Methods和Results-The库奥皮奥颅内动脉瘤数据库包括所有4253 sIA和125 fIA患者从其东芬兰集水区人口，和13009匹配的人口控制和18455一级亲属的IA患者被确定，和芬兰国家登记册被用来识别患有AA的个人。使用与AA相关的37个基因的外显子组基因面板研究了总共33名fIA患者。17例（14.4%）fIA患者和48例（1.2%）sIA患者诊断为AA。fIA和sIA患者的AA发生率均显著高于对照组（1.2%和0.5%）或亲属（0.9%和0.3%）。在竞争风险考克斯回归模型中，fIA的存在是AA的最强风险因素（子分布风险比7.6，95% CI 3.9-14.9，P
Background-Varying degrees of co-occurrence of intracranial aneurysms (IA) and aortic aneurysms (AA) have been reported. We sought to compare the risk for AA in fusiform intracranial aneurysms (fIA) and saccular intracranial aneurysms (sIA) disease and evaluate possible genetic connection between the fIA disease and AAs. Additionally, the characteristics and aneurysms of the fIA and sIA patients were compared.Methods and Results-The Kuopio Intracranial Aneurysm Database includes all 4253 sIA and 125 fIA patients from its Eastern Finnish catchment population, and 13 009 matched population controls and 18 455 first-degree relatives to the IA patients were identified, and the Finnish national registers were used to identify the individuals with AA. A total of 33 fIA patients were studied using an exomic gene panel of 37 genes associated with AAs. Seventeen (14.4%) fIA patients and 48 (1.2%) sIA patients had a diagnosis of AA. Both fIA and sIA patients had AAs significantly more often than their controls (1.2% and 0.5%) or relatives (0.9% and 0.3%). In a competing risks Cox regression model, the presence of fIA was the strongest risk factor for AA (subdistribution hazard ratio 7.6, 95% CI 3.9-14.9, P