Intrinsically Photosensitive (Melanopsin) Retinal Ganglion Cell Function in Glaucoma
Intrinsically Photosensitive (Melanopsin) Retinal Ganglion Cell Function in Glaucoma
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DOI：
10.1167/iovs.10-7069
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发表时间：
2011-06-01
影响因子：
4.4
通讯作者：
Zele, Andrew J.
中科院分区：
文献类型：
--
作者：
Feigl, Beatrix;Mattes, Dietmar;Zele, Andrew J.
目的.确定青光眼是否改变视网膜神经节细胞（ipRGC）的功能。对41名患者（25名青光眼患者和16名年龄匹配的健康对照参与者）进行了测试。视网膜内光敏神经节细胞的功能直接测量的持续，照明后瞳孔反应（PIPR）。41名参与者的41只眼睛接受了7度，10秒，短波长（488 nm;蓝色）和长波长（610 nm;红色）刺激（14.2 log光子）的测试。cm（-2）。s（-1））以麦克斯韦视图呈现给右眼，并通过红外瞳孔测量法测量左眼的一致瞳孔反应。PPR振幅（基线瞳孔直径百分比）、净PPR（百分比变化）和动力学（时间，单位mm）之间的差异。s（-1）至PIPR平台期），并将早期和晚期（中度/重度）青光眼患者的蓝色和红色刺激与年龄匹配的对照参与者进行比较。正常组与晚期青光眼组、早期青光眼组与晚期青光眼组之间的蓝色PIPR均显著小于对照组（P < 0.05）。红色和蓝色PIPR的动力学在任何组之间均无显著差异。年龄匹配的正常受试者和早期青光眼患者在任何参数上均无显著差异，正常组和青光眼组（晚期和早期合并）也无显著差异。患有中度和重度青光眼的人具有功能失调的ipRGC介导的PIPR。用PIPR直接测量视网膜内光敏神经节细胞功能可能成为青光眼进行性变化的临床指标。（Invest Ophthalmol维斯科学。2011;52：4362-4367）DOI：10.1167/iovs.10-7069
PURPOSE. To determine whether glaucoma alters intrinsically photosensitive retinal ganglion cell (ipRGC) function.METHODS. Forty-one patients (25 with glaucoma and 16 healthy age-matched control participants) were tested. Intrinsically photosensitive retinal ganglion cell function was directly measured by the sustained, postillumination pupil response (PIPR). Forty-one eyes of 41 participants were tested with 7 degrees, 10-second, short-wavelength (488 nm; bluish) and long-wavelength (610 nm; reddish) stimuli (14.2 log photons . cm(-2) . s(-1)) presented to the right eye in Maxwellian view, and the consensual pupil response of the left eye was measured by infrared pupillometry. The difference between PIPR amplitude (percentage baseline pupil diameter), net PIPR (percentage change) and kinetics (time in mm . s(-1) to the PIPR plateau) for the blue and red stimuli in patients with early and advanced (moderate/severe) glaucoma was compared to that in age-matched control participants.RESULTS. The blue PIPR was significantly smaller between normal participants and patients with advanced glaucoma, as well as between those with early and those with advanced glaucoma (P < 0.05). The kinetics of the red and blue PIPRs were not significantly different between any groups. Normal age-matched participants and patients with early-stage glaucoma were not significantly different on any parameter, and neither was the normal and glaucoma group (advanced and early combined).CONCLUSIONS. Persons with moderate and severe glaucoma have a dysfunctional ipRGC-mediated PIPR. Intrinsically photosensitive retinal ganglion cell function measured directly with the PIPR may become a clinical indicator of progressive changes in glaucoma. (Invest Ophthalmol Vis Sci. 2011;52:4362-4367) DOI:10.1167/iovs.10-7069