Importin alpha: a multipurpose nuclear-transport receptor.
Importin alpha: a multipurpose nuclear-transport receptor.
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发表时间：
2004
影响因子：
19
通讯作者：
D. Goldfarb;A. Corbett;D. A. Mason;Michelle T. Harreman;S. Adam
中科院分区：
文献类型：
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作者：
D. Goldfarb;A. Corbett;D. A. Mason;Michelle T. Harreman;S. Adam
importin α/β异二聚体将数百种蛋白质靶向核孔复合物（NPC），并促进它们穿过核膜的易位。输入蛋白α结合经典的核定位信号（cNLS）的蛋白质，并将它们连接到输入蛋白β，核转运蛋白的渡轮通过NPC的三元复合物。第二个核转运蛋白，输出蛋白CAS，将输入蛋白α送回细胞质。在这篇文章中，我们讨论了控制机制，输入素α施加的装配和拆卸的三元复合物，我们描述了如何新的组的输入素α基因出现在后生动物的进化过程中的功能，在发展和分化。我们还描述了活动的importin α，似乎是不同的管家功能，在核运输。
The importin alpha/beta heterodimer targets hundreds of proteins to the nuclear-pore complex (NPC) and facilitates their translocation across the nuclear envelope. Importin alpha binds to classical nuclear localization signal (cNLS)-containing proteins and links them to importin beta, the karyopherin that ferries the ternary complex through the NPC. A second karyopherin, the exportin CAS, recycles importin alpha back to the cytoplasm. In this article, we discuss control mechanisms that importin alpha exerts over the assembly and disassembly of the ternary complex and we describe how new groups of importin alpha genes arose during the evolution of metazoan animals to function in development and differentiation. We also describe activities of importin alpha that seem to be distinct from its housekeeping functions in nuclear transport.