Ion channels in T lymphocytes.
Ion channels in T lymphocytes.
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T 淋巴细胞中的离子通道。
DOI：
10.1007/978-1-4684-5323-2_9
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发表时间：
1987
影响因子：
--
通讯作者：
Sutro,JB
中科院分区：
文献类型：
--
作者：
Cahalan,MD;Chandy,KG;DeCoursey,TE;Gupta,S;Lewis,RS;Sutro,JB
离子通道是一种控制离子通过细胞膜的蛋白质，它控制着一系列令人印象深刻的生理过程，包括神经冲动的传导、突触传递、激素分泌、心跳的产生、肌肉收缩的启动和感觉刺激的转导。在很大程度上，这种功能的多样性反映了离子通道类型的多样性。几种不同的通道类型已在神经元中使用各种电生理技术进行了表征（表1;另见参考文献1）。在过去的几年中，在神经系统外的细胞中观察到了一些相同的通道类型，这增加了离子通道可能在电不可兴奋组织中发挥功能的可能性，这些功能与它们在神经系统中的电活动截然不同。事实上，一系列直接和间接的观察结果表明，与神经和肌肉中发现的离子通道类似的离子通道参与控制与细胞增殖和细胞因子产生相关的生物事件，这些生物事件对免疫系统的功能至关重要。
Ion channels, proteins that gate the flux of ions across the cell membrane, control an impressive array of physiological processes, including conduction of nerve impulses, synaptic transmission, hormone secretion, generation of the heart beat, initiation of muscle contraction, and transduction of sensory stimuli. To a large extent, this diversity of functions is a reflection of the diversity of ion channel types. Several distinct channel types have been characterized in neurons using a variety of electrophysiological techniques (Table 1; see also ref. 1). In the past several years, some of the same channel types have been observed in cells outside the nervous system, raising the possibility that ion channels may serve functions in electrically non-excitable tissues that are quite distinct from their electrical activities in the nervous system. In fact, a collection of direct and indirect observations suggests that ion channels similar to those found in nerve and muscle participate in the control of biological events associated with cellular proliferation and cytokine production that are crucial to the functioning of the immune system.