Optoacoustic technique for noninvasive monitoring of blood oxygenation: a feasibility study
Optoacoustic technique for noninvasive monitoring of blood oxygenation: a feasibility study
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DOI：
10.1364/ao.41.004722
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发表时间：
2002-08-01
期刊：
影响因子：
1.9
通讯作者：
Prough, DS
中科院分区：
文献类型：
--
作者：
Esenaliev, RO;Larina, IV;Prough, DS
用无创技术取代有创脑静脉氧合监测为包括创伤性脑损伤在内的危及生命的神经系统疾病的管理提供了巨大的希望。我们开发并建立了一个光声系统，以无创监测脑静脉氧合;该系统包括纳秒Nd：YAG激光器和专门设计的光声探头。我们测试了系统在体外羊血与实验不同的氧合。我们的研究结果表明：（1）光声波的幅度和时间分布随着血氧含量在24%至92%的范围内增加，（2）尽管厚骨对光声信号有衰减，但仍可以检测到光声信号，（3）该系统能够进行实时和连续测量。这些结果表明，光声技术是技术上可行的连续，无创监测脑静脉氧合。(C)2002年美国光学学会。
Replacement of invasive monitoring of cerebral venous oxygenation with noninvasive techniques offers great promise in the management of life-threatening neurologic illnesses including traumatic brain injury. We developed and built an optoacoustic system to noninvasively monitor cerebral venous oxygenation; the system includes a nanosecond Nd:YAG laser and a specially designed optoacoustic probe. We tested the system in vitro in sheep blood with experimentally varied oxygenation. Our results demonstrated that (1) the amplitude and temporal profile of the optoacoustic waves increase with blood oxygenation in the range from 24% to 92%, (2) optoacoustic signals can be detected despite optical and acoustic attenuation by thick bone, and (3) the system is capable of real-time and continuous measurements. These results suggest that the optoacoustic technique is technically feasible for continuous, noninvasive monitoring of cerebral venous oxygenation. (C) 2002 Optical Society of America.