HYPERHOMOCYSTEINEMIA AND LOW PYRIDOXAL-PHOSPHATE - COMMON AND INDEPENDENT REVERSIBLE RISK-FACTORS FOR CORONARY-ARTERY DISEASE
HYPERHOMOCYSTEINEMIA AND LOW PYRIDOXAL-PHOSPHATE - COMMON AND INDEPENDENT REVERSIBLE RISK-FACTORS FOR CORONARY-ARTERY DISEASE
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DOI：
10.1161/01.cir.92.10.2825
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发表时间：
1995-11-15
期刊：
影响因子：
37.8
通讯作者：
JACOBSEN, DW
中科院分区：
文献类型：
--
作者：
ROBINSON, K;MAYER, EL;JACOBSEN, DW
高血浆同型半胱氨酸与男性早发冠状动脉疾病相关，但定义这种风险的阈值浓度及其在女性和老年人中的重要性尚不清楚。此外，虽然低B族维生素状态增加同型半胱氨酸，这些维生素和冠心病之间的联系尚不清楚。方法和结果我们比较了304例冠心病患者与231名对照组。记录了危险因素和血浆同型半胱氨酸、叶酸、维生素B12和吡哆醛5 '-磷酸盐的浓度。同型半胱氨酸浓度为14 μ mol/L时，冠心病的优势比为4.8（P
Background High plasma homocysteine is associated with premature coronary artery disease in men, but the threshold concentration defining this risk and its importance in women and the elderly are unknown. Furthermore, although low B vitamin status increases homocysteine, the link between these vitamins and coronary disease is unclear.Methods and Results We compared 304 patients with coronary disease with 231 control subjects. Risk factors and concentrations of plasma homocysteine, folate, vitamin B12, and pyridoxal 5'-phosphate were documented. A homocysteine concentration of 14 mu mol/L conferred an odds ratio of coronary disease of 4.8 (P