Neuropilin‑1 as a new potential SARS‑CoV‑2 infection mediator implicated in the neurologic features and central nervous system involvement of COVID‑19.
Neuropilin‑1 as a new potential SARS‑CoV‑2 infection mediator implicated in the neurologic features and central nervous system involvement of COVID‑19.
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DOI：
10.3892/mmr.2020.11510
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发表时间：
2020-11
影响因子：
3.4
通讯作者：
Kyrou I
中科院分区：
文献类型：
--
作者：
Davies J;Randeva HS;Chatha K;Hall M;Spandidos DA;Karteris E;Kyrou I
严重急性呼吸综合征（SARS）冠状病毒2型（SARS-CoV-2）感染是新型病毒性传染病（2019冠状病毒病; COVID-19）的病因。新出现的证据表明，COVID-19可能与广泛的神经系统症状和涉及中枢神经系统（CNS）的并发症有关。目前已证实SARS-CoV-2的刺突蛋白主要通过与血管紧张素转换酶2（ACE-2）结合而促进SARS-CoV-2进入宿主细胞。临床前研究表明，神经纤毛蛋白-1（NRP 1）是一种缺乏胞浆蛋白激酶结构域的跨膜受体，在呼吸和嗅觉上皮中表现出高表达，也可能通过增强SARS-CoV-2通过嗅觉上皮进入大脑而与COVID-19有关。在本研究中，我们扩展了这些发现，并证明NRP 1也在CNS中表达，包括嗅觉相关区域，如嗅结节和嗅旁回。这进一步支持了NRP 1作为与COVID-19的神经学表现有关的额外SARS-CoV-2感染介体的潜在作用。因此，SARS-CoV-2通过CNS中NRP 1表达细胞的嗜神经性值得进一步研究。
Infection by the severe acute respiratory syndrome (SARS) coronavirus-2 (SARS-CoV-2) is the cause of the new viral infectious disease (coronavirus disease 2019; COVID-19). Emerging evidence indicates that COVID-19 may be associated with a wide spectrum of neurological symptoms and complications with central nervous system (CNS) involvement. It is now well-established that entry of SARS-CoV-2 into host cells is facilitated by its spike proteins mainly through binding to the angiotensin-converting enzyme 2 (ACE-2). Preclinical studies have suggested that neuropilin-1 (NRP1), which is a transmembrane receptor that lacks a cytosolic protein kinase domain and exhibits high expression in the respiratory and olfactory epithelium, may also be implicated in COVID-19 by enhancing the entry of SARS-CoV-2 into the brain through the olfactory epithelium. In the present study, we expand on these findings and demonstrate that the NRP1 is also expressed in the CNS, including olfactory-related regions such as the olfactory tubercles and paraolfactory gyri. This furthers supports the potential role of NRP1 as an additional SARS-CoV-2 infection mediator implicated in the neurologic manifestations of COVID-19. Accordingly, the neurotropism of SARS-CoV-2 via NRP1-expressing cells in the CNS merits further investigation.
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DOI：
10.1109/tcbb.2020.3009099
发表时间：
2021-07-01
影响因子：
4.5
作者：
Cui, Chunmei;Huang, Chuanbo;Cui, Qinghua
通讯作者：
Cui, Qinghua
影响因子：
11.8
作者：
Lau KK;Yu WC;Chu CM;Lau ST;Sheng B;Yuen KY
通讯作者：
Yuen KY
影响因子：
64.8
作者：
Hawrylycz, Michael J.;Lein, Ed S.;Guillozet-Bongaarts, Angela L.;Shen, Elaine H.;Ng, Lydia;Miller, Jeremy A.;van de lagemaat, Louie N.;Smith, Kimberly A.;Ebbert, Amanda;Riley, Zackery L.;Abajian, Chris;Beckmann, Christian F.;Bernard, Amy;Bertagnolli, Darren;Boe, Andrew F.;Cartagena, Preston M.;Chakravarty, M. Mallar;Chapin, Mike;Chong, Jimmy;Dalley, Rachel A.;Daly, Barry David;Dang, Chinh;Datta, Suvro;Dee, Nick;Dolbeare, Tim A.;Faber, Vance;Feng, David;Fowler, David R.;Goldy, Jeff;Gregor, Benjamin W.;Haradon, Zeb;Haynor, David R.;Hohmann, John G.;Horvath, Steve;Howard, Robert E.;Jeromin, Andreas;Jochim, Jayson M.;Kinnunen, Marty;Lau, Christopher;Lazarz, Evan T.;Lee, Changkyu;Lemon, Tracy A.;Li, Ling;Li, Yang;Morris, John A.;Overly, Caroline C.;Parker, Patrick D.;Parry, Sheana E.;Reding, Melissa;Royall, Joshua J.;Schulkin, Jay;Sequeira, Pedro Adolfo;Slaughterbeck, Clifford R.;Smith, Simon C.;Sodt, Andy J.;Sunkin, Susan M.;Swanson, Beryl E.;Vawter, Marquis P.;Williams, Derric;Wohnoutka, Paul;Zielke, H. Ronald;Geschwind, Daniel H.;Hof, Patrick R.;Smith, Stephen M.;Koch, Christof;Grant, Seth G. N.;Jones, Allan R.
通讯作者：
Jones, Allan R.
COVID-19 大流行：考虑脑部感染。
影响因子：
3.3
作者：
Mao, Xiao-Yuan;Jin, Wei-Lin
通讯作者：
Jin, Wei-Lin
影响因子：
3.5
作者：
Needham, Edward J.;Chou, Sherry H. -Y.;Menon, David K.
通讯作者：
Menon, David K.