Cold atmospheric plasma, a novel promising anti-cancer treatment modality.
Cold atmospheric plasma, a novel promising anti-cancer treatment modality.
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DOI：
10.18632/oncotarget.13304
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发表时间：
2017-02-28
期刊：
影响因子：
--
通讯作者：
Keidar M
中科院分区：
文献类型：
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作者：
Yan D;Sherman JH;Keidar M
在过去的十年中，冷大气等离子体（CAP），一种接近室温的电离气体，在癌症治疗中显示出了其广阔的应用前景。两种 CAP 装置，即介质阻挡放电和等离子喷射，在体外对数十种癌细胞系和体内几种皮下异种移植肿瘤显示出显着的抗癌能力。与传统的抗癌方法和药物相比，CAP 是一种选择性抗癌治疗方式。迄今为止，CAP 抗癌能力的化学和分子机制的建立还远未完成。在这篇综述中，我们向癌症生物学家全面介绍了 CAP 的基础知识、该领域的最新研究进展、主要挑战和未来方向。
Over the past decade, cold atmospheric plasma (CAP), a near room temperature ionized gas has shown its promising application in cancer therapy. Two CAP devices, namely dielectric barrier discharge and plasma jet, show significantly anti-cancer capacity over dozens of cancer cell lines in vitro and several subcutaneous xenograft tumors in vivo. In contrast to conventional anti-cancer approaches and drugs, CAP is a selective anti-cancer treatment modality. Thus far establishing the chemical and molecular mechanism of the anti-cancer capacity of CAP is far from complete. In this review, we provide a comprehensive introduction of the basics of CAP, state of the art research in this field, the primary challenges, and future directions to cancer biologists.