Silencing LMNB1 Contributes to the Suppression of Lung Adenocarcinoma Development.
Silencing LMNB1 Contributes to the Suppression of Lung Adenocarcinoma Development.
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沉默 LMNB1 有助于抑制肺腺癌的发展
DOI：
10.2147/cmar.s275874
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发表时间：
2021
影响因子：
3.3
通讯作者：
Xu X
中科院分区：
文献类型：
--
作者：
Tang D;Luo H;Xie A;He Z;Zou B;Xu F;Zhang W;Xu X
近年来，肺癌已被公认为是发病率和死亡率最高的致命恶性肿瘤。在本研究中，我们发现LMNB1是核骨架的重要组成蛋白，在肺腺癌（LUAD）中显着上调，并与病理分期以及淋巴转移相关。利用 LMNB1 敲低 LUAD 细胞系进行的体外功能丧失研究表明，LMNB1 的缺失通过调节细胞增殖、细胞凋亡、细胞周期和细胞运动来抑制 LUAD 的发育。在小鼠异种移植模型中证明了 LMNB1 敲低 LUAD 细胞的肿瘤发生减少。此外，通过凋亡相关蛋白和癌症相关信号通路的表达评估，探讨了LMNB1促进LUAD的机制。总之，我们的研究确定 LMNB1 是 LUAD 的肿瘤启动子和潜在的治疗靶点。
Lung cancer has been recognized as the most fatal malignant tumor with the highest morbidity and mortality in recent years. In this study, we found that LMNB1, which is an important component protein of the nuclear skeleton, was significantly upregulated in lung adenocarcinoma (LUAD) and correlated with the pathological stage as well as lymphatic metastasis. In vitro loss-of-function study utilizing LMNB1 knockdown LUAD cell lines demonstrated that depletion of LMNB1 inhibited development of LUAD through regulating cell proliferation, cell apoptosis, cell cycle and cell motility. Decreased tumorigenesis of LMNB1 knockdown LUAD cells was proved in mice xenograft models. Moreover, the mechanism by which LMNB1 promotes LUAD was explored through the expression evaluation of apoptosis-related proteins and cancer-related signaling pathways. In conclusion, our study identified LMNB1 as a tumor promotor and a potential therapeutic target in LUAD.