Pharmacokinetic Modeling of dynamic contrast-enhanced MRI of the hand and wrist in rheumatoid arthritis and the response to anti-tumor necrosis factor-α therapy
Pharmacokinetic Modeling of dynamic contrast-enhanced MRI of the hand and wrist in rheumatoid arthritis and the response to anti-tumor necrosis factor-α therapy
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DOI：
10.1002/mrm.21349
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发表时间：
2007-09-01
影响因子：
3.3
通讯作者：
Moots, Robert
中科院分区：
文献类型：
--
作者：
Hodgson, Richard J.;Connolly, Sylvia;Moots, Robert
对11例类风湿性关节炎患者在抗肿瘤坏死因子（TNF）-α治疗前和治疗后2周分别进行两次手部和腕部动态增强MRI（DCE-MRI）检查。动态成像采用快速T1加权三维扰相梯度回波（SPGR）序列。使用在不同翻转角下获得的相似图像进行T，估计。相对射频场由已知的动脉周围脂肪骨髓的T1估计。在每次检查时测量动脉输入功能（AIF），并将其标准化为预期血浆浓度以减少部分容积效应。对滑膜增强进行建模，以产生K-transs、v（e）和v（p）的值，Ktranss和v显示出良好的再现性。治疗2周后，K-transs显著降低约20%。本研究证明了DCE-MRI和phar macokinetic建模在研究治疗后类风湿性关节炎中炎症活性的早期变化方面的潜力。
Dynamic contrast-enhanced MRI (DCE-MRI) of the hand an wrist was performed in 11 patients with rheumatoid arthriti twice before and once 2 weeks after treatment with anti-tumor necrosis factor (TNF)-alpha therapy. A rapid, T-1-weighted 3D spoiled gradient echo (SPGR) sequence was used for the dy namic imaging. T, estimation was performed using similar im ages obtained at different flip angles. The relative radiofre quency field was estimated from the known T, of the periartic ular fatty marrow. The arterial input function (AIF) wa measured at each examination, and normalized to the expectec plasma concentration to reduce partial volume effects. Synovia enhancement was modeled to yield values for K-trans, v(e), and v(p) Ktrans and v. showed good reproducibility. There was a signifi cant decrease of about 20% in K-trans after 2 weeks of treatment This study demonstrates the potential of DCE-MRI and phar macokinetic modeling to study early changes in inflammatory activity in rheumatoid arthritis following treatment.