B-cell compartment abnormalities are associated with ACLF and mortality in patients with liver cirrhosis
B-cell compartment abnormalities are associated with ACLF and mortality in patients with liver cirrhosis
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DOI：
10.1016/j.clinre.2021.101698
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发表时间：
2021-05-01
影响因子：
2.7
通讯作者：
Santos-Silva, Maria Claudia
中科院分区：
文献类型：
--
作者：
Cardoso, Chandra Chiappin;Matiollo, Camila;Santos-Silva, Maria Claudia
背景资料：肝硬化严重影响免疫系统，导致免疫失衡，称为肝硬化相关免疫功能障碍。目的：本研究旨在探讨肝硬化急性失代偿期（AD）患者B细胞功能紊乱与预后及死亡率的关系。方法：本研究包括39例AD肝硬化患者、29例稳定性肝硬化（SC）患者和30例健康对照者（CTR）。通过流式细胞术测定循环B细胞亚群和细胞因子血浆水平。
Background: Liver cirrhosis profoundly affects the immune system, leading to an immunological imbalance known as cirrhosis-associated immune dysfunction. Aims: This study aimed to investigate B-cell disturbances in patients with acute decompensation (AD) of cirrhosis and assess relationships with prognosis and mortality.Methods: The study included 39 patients with AD of cirrhosis, 29 patients with stable cirrhosis (SC), and 30 healthy controls (CTR). Circulating B-cell subsets and cytokine plasma levels were determined by flow cytometry.