Effects of "binge" use of intravenous cocaine in methadone-maintained individuals
Effects of "binge" use of intravenous cocaine in methadone-maintained individuals
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DOI：
10.1046/j.1360-0443.1998.9368254.x
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发表时间：
1998-06-01
期刊：
影响因子：
6
通讯作者：
Fischman, MW
中科院分区：
文献类型：
--
作者：
Foltin, RW;Fischman, MW
目标。研究大量使用可卡因后戒断的影响。设计在下午和晚上进行的自我给药期间，参与者可以以14分钟的间隔自我给药多达6剂静脉注射可卡因（32 mg/70 kg）。所有志愿者都参加了为期2天和3天的一系列自我给药（可卡因狂欢）。在每次可卡因狂欢后至少2天内可获得Nb可卡因。参与者五名成年美沙酮维持可卡因滥用者。设置.住院临床研究单位。测量.心血管和主观影响。调查结果。第一次可卡因剂量在一个会话中产生了大量的主观和心血管效应，除了血压和“易怒”的评级，给予多达五个可卡因剂量也没有增加这些影响。然而，额外的可卡因剂量确实增加了“不良药物效应”的评分，并降低了“我想要可卡因”的评分：可卡因的最大主观和心血管效应在同一天或不同天之间没有变化。“抑郁”和“悲惨”的评级增加后的第一天，每个时期的可卡因使用，并介绍可卡因相关的刺激增加评级“我要可卡因”和“我要海洛因”在可卡因戒断。结论.在美沙酮维持的个体中，可卡因狂欢期间对可卡因的许多作用产生了急性耐受性，第二天情绪的残余变化是微妙的，并且没有观察到可卡因狂欢的长期影响。
Aims. To examine the effects of heavy cocaine use followed by abstinence. Design. During self-administration sessions, which occurred in the afternoon and again in the evening, participants could self-administer up to six doses of intravenous cocaine (32 mg/70 kg) at 14-minute intervals. All volunteers participated in a 2-day and a 3-day series of self-administration sessions (cocaine binges). Nb cocaine was available for at least 2 days following each cocaine binge. Participants. Five adult methadone-maintained cocaine abusers. Setting. Inpatient clinical research unit. Measurements. Cardiovascular and subjective effects. Findings. The first cocaine dose in a session produced substantial subjective and cardiovascular effects and, with the exception of blood pressure and ratings of "irritable", administering up to five more cocaine doses did nor increase these effects. Additional cocaine doses, however, did increase ratings of "bad drug effect" and decrease ratings of "I want cocaine": Maximal subjective and cardiovascular effects of cocaine did not vary across sessions on the same day or between days. Ratings of "depressed" and "miserable" were increased the first day after each period of cocaine use, and presentation of cocaine-related stimuli increased ratings of "I want cocaine" and "I want heroin" during cocaine abstinence. Conclusions. Acute tolerance developed to many of the effects of cocaine during a cocaine binge in methadone-maintained individuals, next-day residual changes in mood were subtle, and no prolonged effects of a cocaine binge were observed.