Use of viral vectors for vaccine production in plants
Use of viral vectors for vaccine production in plants
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DOI：
10.1111/j.1440-1711.2005.01339.x
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发表时间：
2005-06-01
影响因子：
4
通讯作者：
Lomonossoff, GP
中科院分区：
文献类型：
--
作者：
Ca単izares, MC;Nicholson, L;Lomonossoff, GP
植物病毒基因组尺寸小、易于操作以及感染过程简单，使得病毒载体成为植物中表达外源蛋白的转基因系统的有吸引力的替代品。这些病毒表达系统的用途之一是用于疫苗生产。已开发出两种基本类型的病毒系统用于在植物中生产免疫原性肽和蛋白质：表位呈递系统和多肽表达系统。在这篇综述中，我们讨论了该领域取得的进展。
The small size of plant viral genomes, the ease with which they can be manipulated, and the simplicity of the infection process is making the viral vectors an attractive alternative to the transgenic systems for the expression of foreign proteins in plants. One use of these virus expression systems is for vaccine production. There are two basic types of viral system that have been developed for the production of immunogenic peptides and proteins in plants: epitope presentation and polypeptide expression systems. In this review, we discuss advances made in this field.