Post-training, but not post-reactivation, administration of amphetamine and anisomycin modulates Pavlovian conditioned approach
Post-training, but not post-reactivation, administration of amphetamine and anisomycin modulates Pavlovian conditioned approach
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DOI：
10.1016/j.nlm.2006.12.007
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发表时间：
2007-05-01
影响因子：
2.7
通讯作者：
Janak, Patricia H.
中科院分区：
文献类型：
--
作者：
Blaiss, Cory A.;Janak, Patricia H.
精神兴奋剂安非他明 (AMPH) 和蛋白质合成抑制剂茴香霉素 (ANI) 已被证明可以调节多种学习类型的巩固和再巩固。为了确定巴甫洛夫条件方法 (PCA) 是否以类似的方式调节，我们检查了训练后和重新激活后施用 AMPH 和 ANI 对 PCA 记忆的影响。雄性 Long-Evans 大鼠接受 PCA 训练，训练期间先进行 CS+，然后进行蔗糖输送。 AMPH（1 mg/kg，皮下注射）在第一次训练后立即注射（但不是在 6 小时后）增强了 PCA 行为。立即注射 ANI（150 mg/kg，皮下注射），但在第一次训练后不注射 3 It，损害 PCA 行为。这种损害并不是由于条件性味觉厌恶的发展造成的。为了检查 PCA 是否也可以通过 AMPH 和 ANI 的重新激活后给药来调节，在记忆重新激活后立即给大鼠注射 AMPH、ANI 或媒介物。经测试，AMPH 和 ANI 治疗的大鼠的行为均未受到影响。当改变各种行为参数（即训练量、记忆重新激活的长度）重复实验时，该结果保持一致。这些研究结果表明，AMPH 和 ANI 在训练后（而非重新激活后）期间分别发挥作用，增强和损害 PCA 的学习。这表明 PCA 的巩固可以通过与其他类型的习得关联相当的方式进行调节，但一旦习得，记忆似乎相对稳健且稳定。 (C) 2006 Elsevier Inc. 保留所有权利。
The psychostimulant, amphetamine (AMPH), and the protein synthesis inhibitor, anisomycin (ANI), have been shown to modulate the consolidation and reconsolidation of several types of learning. To determine whether Pavlovian conditioned approach (PCA) is modulated in a similar manner, we examined the effects of post-training and post-reactivation administration of both AMPH and ANI on memory for PCA. Male Long-Evans rats received PCA training sessions during which presentations of a CS+ were followed by sucrose delivery. AMPH (1 mg/kg, s.c.) injected immediately but not 6 h after the first training session enhanced PCA behavior. ANI (150 mg/kg, s.c.) injected immediately but not 3 It after the first training session impaired PCA behavior. This impairment was not due to the development of a conditioned taste aversion. To examine whether PCA can also be modulated by post-reactivation administration of AMPH and ANI, rats were given an injection of AMPH, ANI, or vehicle immediately after a memory reactivation session. Upon testing, the behavior of both the AMPH- and the ANI-treated rats was unaffected. This result remained consistent when the experiment was repeated with changes to various behavioral parameters (i.e., amount of training, length of memory reactivation). These findings indicate that AMPH and ANI act during the post-training but not the post-reactivation period to enhance and impair, respectively, the learning of PCA. This suggests that the consolidation of PCA can be modulated in a manner comparable to other types of learned associations, but once learned, the memory appears to be relatively robust and stable. (C) 2006 Elsevier Inc. All rights reserved.