Surface analyses and immune reactivities of major cell wall-associated proteins of group A streptococcus
Surface analyses and immune reactivities of major cell wall-associated proteins of group A streptococcus
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DOI：
10.1128/iai.73.5.3137-3146.2005
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发表时间：
2005-05-01
影响因子：
3.1
通讯作者：
Walker, MJ
中科院分区：
文献类型：
--
作者：
Cole, JN;Ramirez, RD;Walker, MJ
用蛋白质组学方法鉴定了化脓性链球菌的细胞壁相关蛋白。鉴定了74个不同的细胞壁相关蛋白，其中66个是新发现的。33个蛋白与化脓性链球菌反应性人抗血清发生免疫反应。GAS细胞表面的生物素化鉴定出23种与细胞壁相关的蛋白，这些蛋白都暴露在表面。
A proteomic analysis was undertaken to identify cell wall-associated proteins of Streptococcus pyogenes. Seventy-four distinct cell wall-associated proteins were identified, 66 of which were novel. Thirty-three proteins were immunoreactive with pooled S. pyogenes-reactive human antisera. Biotinylation of the GAS cell surface identified 23 cell wall-associated proteins that are surface exposed.