Development of radiographic damage during the first 5-6 yr of rheumatoid arthritis. A prospective follow-up study of a Swedish cohort.
Development of radiographic damage during the first 5-6 yr of rheumatoid arthritis. A prospective follow-up study of a Swedish cohort.
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类风湿性关节炎最初 5-6 年期间放射线损伤的发展。
DOI：
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发表时间：
1996
期刊：
影响因子：
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通讯作者：
K. Eberhardt
中科院分区：
文献类型：
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作者：
E. Fex;K. Jonsson;U. Johnson;K. Eberhardt
本研究的目的是描述类风湿关节炎患者放射学损害的发展，并寻找5年以上放射学进展的预测因子。113例患者，75名女性和38名男性，平均年龄53岁，明确的RA和平均疾病持续时间为11.4个月，前瞻性随访5年，在门诊诊所。每年进行一次手和脚的X光片，并根据Larsen进行评价。在研究开始时评估人口统计学、临床和实验室变量的预测价值。采用逐步logistic回归模型。我们发现，放射性关节损伤发生早期，并在5年的研究中显着进步。进展率在前2年最为显著。在研究开始时，53%的患者没有可检测到的糜烂，但只有11%的患者保持非糜烂。26%的最初存在糜烂的患者没有实质性进展，不需要积极的治疗。第一年内关节损伤进展率高、女性和基线ESR高可预测57%的患者影像学进展率高。年龄、病程、类风湿因子、遗传因素、活动关节计数和研究开始时是否存在糜烂没有预测价值。
The objective of this study was to describe the development of radiographic damage in patients with RA and to search for predictors of radiographic progression over 5 yr. One hundred and thirteen patients, 75 female and 38 male, mean age 53 yr, with definite RA and mean disease duration of 11.4 months, were followed prospectively for 5 yr at an out-patient clinic. Radiographs of the hands and feet were performed annually, and evaluated according to Larsen. The predictive value of demographic, clinical and laboratory variables at study start was evaluated. A stepwise logistic regression model was applied. We found that radiological joint damage occurred early and was significantly progressive during the 5 study years. The rate of progression was most prominent during the first 2 yr. At study start, 53% of the patients had no detectable erosions, but only 11% remained non-erosive. Twenty-six per cent of the patients with the initial presence of erosions did not progress substantially and needed no aggressive therapy. High joint damage progression during the first year, female gender and high baseline ESR could predict 57% of the patients with high total radiographic progression. Age, disease duration, rheumatoid factor, genetic factors, active joint count and the presence of erosions at study start had no predictive value.
影响因子：
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作者：
DEAL, CL;MEENAN, RF;COHEN, AS
通讯作者：
COHEN, AS
类风湿性关节炎在疾病的前 2 年内有显着的放射学损伤的证据。
DOI：
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发表时间：
1989
期刊：
The Journal of rheumatology
影响因子：
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作者：
Fuchs,HA;Kaye,JJ;Callahan,LF;Nance,EP;Pincus,T
通讯作者：
Pincus,T