POST-TRAINING SYSTEMIC AND INTRA-AMYGDALA ADMINISTRATION OF THE GABA-B AGONIST BACLOFEN IMPAIRS RETENTION
POST-TRAINING SYSTEMIC AND INTRA-AMYGDALA ADMINISTRATION OF THE GABA-B AGONIST BACLOFEN IMPAIRS RETENTION
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DOI：
10.1016/s0163-1047(89)90285-9
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发表时间：
1989-09-01
期刊：
影响因子：
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通讯作者：
MCGAUGH, JL
中科院分区：
文献类型：
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作者：
CASTELLANO, C;BRIONI, JD;MCGAUGH, JL
通过两个系列的实验研究了GABA-B受体激动剂巴氯芬对记忆存储的影响。在第一个系列中，CD-1小鼠被训练了两种厌恶动机任务：一次尝试抑制性回避任务和一种经典的条件性情绪反应任务(条件情绪反应)。训练后立即ip(+/-)巴氯芬(10 mg/kg和30 mg/kg)会损害动物在两种任务中的保持能力。这种效应是时间依赖的：训练后120分钟给药不影响记忆保持。在第二组实验中，使用了SpragueDawley大鼠，训练后杏仁核内注射巴氯芬削弱了抑制性回避反应的保持。这些结果支持这样的观点，即GABA能系统参与了记忆存储的调制，杏仁核复合体可能是影响GABA能系统的药物作用的关键部位。
The effects of the GABA-B receptor agonist baclofen on memory storage were studied in two series of experiments. In the first series, CD-1 mice were trained in two aversively motivated tasks: A one-trial inhibitory avoidance task and a classical conditioning task (conditional emotional response). Immediate post-training ip administration of (+/-)baclofen (10 and 30 mg/kg) impaired retention of animals in both tasks. The effect was time-dependent: Retention was not affected by baclofen administered 120 min after training. In the second series of experiments, which used Sprague-Dawley rats, post-training intra-amygdala administration of baclofen impaired retention of an inhibitory avoidance response. These results support the view that the GABAergic system is involved in the modulation of memory storage and that the amygdaloid complex may be a critical site for effects of drugs affecting the GABAergic system.