Acute neurite retraction elicited by diverse agents is prevented by genistein, a tyrosine kinase inhibitor.
Acute neurite retraction elicited by diverse agents is prevented by genistein, a tyrosine kinase inhibitor.
复制标题
金雀异黄素（一种酪氨酸激酶抑制剂）可以防止由多种药物引起的急性神经突回缩。
DOI：
10.1111/j.1471-4159.1993.tb03573.x
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发表时间：
1993
影响因子：
4.7
通讯作者：
Smalheiser,NR
中科院分区：
文献类型：
--
作者：
Smalheiser,NR
The retraction of axonal branches is a prominent feature of nervous system development and function. Although various biological and pathological signals can elicit retraction, little is known regarding their underlying mode of action. An in vitro assay using NG108–15 cells was used to demonstrate that rapid‐onset neurites exposed acutely to trypsin, serum, lysophosphatidic acid, extracellular ATP, the phorbol ester phorbol 12‐myristate 13‐acetate, and nocodazole were all protected from retraction by the tyrosine kinase inhibitor genistein. This finding indicates that a common (genistein‐sensitive) cellular event is involved in integrating the influence of multiple extrinsic and intrinsic signals and in regulating whether or not neurites will execute a retraction response.
