Psychometric evaluation of the Functional Assessment of Cancer Therapy/Gynecologic Oncology Group-Neurotoxicity (Fact/GOG-Ntx) questionnaire for patients receiving systemic chemotherapy
Psychometric evaluation of the Functional Assessment of Cancer Therapy/Gynecologic Oncology Group-Neurotoxicity (Fact/GOG-Ntx) questionnaire for patients receiving systemic chemotherapy
复制标题
DOI：
10.1111/j.1525-1438.2003.13603.x
复制
发表时间：
2003-11-01
影响因子：
4.8
通讯作者：
Cella, D
中科院分区：
文献类型：
--
作者：
Calhoun, EA;Welshman, EE;Cella, D
本研究的目的是验证癌症治疗功能评估/妇科肿瘤组-神经毒性（FACT/GOG-Ntx）问卷。FACT/GOG-Ntx是FACT-G加上一个11项子量表（Ntx子量表），用于评价与化疗诱导的神经病变特异性相关的症状和问题。两组卵巢癌女性完成了FACT/GOG-Ntx：一组具有已知的神经毒性，一组新诊断为卵巢癌的化疗初治女性。从卵巢癌诊断到诊断后12个月，评估患者神经病变水平、毒性严重程度和患者生活质量。Ntx子量表在基线和3个月和6个月随访时显著区分了两组，表明化疗初治患者的问题明显少于已知神经病变的患者。FACT/GOG-Ntx是评估神经病变对健康相关生活质量影响的可靠有效工具。Ntx子量表对有意义的临床差异和随时间的变化表现出敏感性。
The purpose of this study was to validate the Functional Assessment of Cancer Therapy/Gynecologic Oncology Group-Neurotoxicity (FACT/GOG-Ntx) questionnaire. The FACT/GOG-Ntx is the FACT-G plus an eleven-item subscale (Ntx subscale) that evaluates symptoms and concerns associated specifically with chemotherapy-induced neuropathy. Two groups of women with ovarian cancer completed the FACT/GOG-Ntx: one group with known neurotoxicities and one group of chemotherapy-naive women newly diagnosed with ovarian cancer. Levels of patient neuropathy, severity of toxicity, and patient quality of life from diagnosis of ovarian cancer to 12 months post-diagnosis were assessed. The Ntx subscale significantly differentiated the two groups at baseline and 3- and 6-month follow-ups, demonstrating significantly fewer problems among chemotherapy-naive patients than among patients with known neuropathy. The FACT/GOG-Ntx is a reliable and valid instrument for assessing the impact of neuropathy on health-related quality of life. The Ntx subscale demonstrated sensitivity to meaningful clinical distinctions and change over time.