Should we instruct patients to rub topical agents into skin? The evidence
Should we instruct patients to rub topical agents into skin? The evidence
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我们是否应该指导患者将外用药物涂抹到皮肤上？
DOI：
10.1080/09546634.2018.1527997
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发表时间：
2018
影响因子：
2.9
通讯作者：
H. Maibach
中科院分区：
文献类型：
--
作者：
Becky S Li;J. Cary;H. Maibach
摘要背景：至少有 15 个因素影响化合物渗透皮肤的能力。按摩（摩擦）可能是另一个相对未被认识的因素。方法：2018 年 3 月在线访问 PubMed、Google Scholar 和 EMBASE 数据库，搜索测量有或没有摩擦或按摩的皮肤吸收情况的研究。结果：虽然一些研究指出摩擦对皮肤吸收没有影响，但其他研究则证明了相反的情况。一般来说，按摩手法有时确实能增强真皮吸收。除了增加皮肤温度和血流量外，摩擦还可能改变角质层 (SC) 结构，从而提高扩散速率并增加皮肤内保留的渗透剂量。结论：了解按摩的机制及其在经皮渗透中的作用可能有助于阐明皮肤屏障功能、真皮吸收、皮肤净化和皮肤毒理学。为了实现这些目标，必须首先建立模拟体内行为的体外模型。随后，可以考虑使用不同的渗透剂、载体、按摩时间和其他变量进行实验。
Abstract Background: At least 15 factors influence the ability of compounds to penetrate the skin. Massage (rubbing) may be another factor that has gone relatively unrecognized. Method: PubMed, Google Scholar, and EMBASE databases were accessed online in March 2018 in search of studies measuring absorption through skin with and without rubbing or massage. Results: While some studies noted no difference in dermal absorption with regards to rubbing, others have demonstrated the opposite. In general, massage technique does indeed sometimes enhance dermal absorption. In addition to increase skin temperature and blood flow, rubbing likely modifies stratum corneum (SC) structure to enhance diffusion rates and increase retained penetrant amount within the skin. Conclusions: Understanding the mechanism of massage and its role in percutaneous penetration may help elucidate skin barrier function, dermal absorption, skin decontamination, and dermatotoxicology. To achieve such goals, an in vitro model that models in vivo behaviors must first be established. Subsequently, experiments with different penetrants, vehicles, massage time, and other variables may be considered.