The dorsomedial striatum mediates flexible choice behavior in spatial tasks
The dorsomedial striatum mediates flexible choice behavior in spatial tasks
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DOI：
10.1016/j.bbr.2011.02.008
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发表时间：
2011-07-07
影响因子：
2.7
通讯作者：
Hauber, Wolfgang
中科院分区：
文献类型：
--
作者：
Braun, Stephanie;Hauber, Wolfgang
背内侧纹状体在行动选择和评估以及基于价值的决策中起着关键作用。啮齿类动物的研究表明，背内侧纹状体（pDMS）的后亚区参与动作-结果关联的获取和表达，以及选择导致奖励位置的动作。然而，目前尚不清楚pDMS是否参与了基于对现有应对方案的努力和结果的评估的行动选择。本研究在大鼠身上研究了pDMS细胞体损伤对成本-收益t迷宫任务中基于努力的决策的影响。在这个任务中，受试者可以选择爬上一个障碍来获得高奖励，或者在没有障碍的情况下，另一只手臂获得低奖励。此外，在奖励分配的空间改变后，本任务考察了pDMS细胞体损伤的影响，以分析选择行为的灵活性。结果显示，在pDMS病变的大鼠中，基于可用反应选项的成本效益比评估的选择行为是完整的。然而，与假对照组相比，pDMS病变大鼠在高、低奖励目标臂的空间反转后，选择行为的灵活性较低。因此，在这里使用的t型迷宫任务中，pDMS可能不支持与努力相关的决策，而是支持空间引导行为的灵活性。(C) 2011 Elsevier B.V.版权所有
The dorsomedial striatum plays a critical role in action selection and evaluation as well as in value-based decision making. Rodent studies implicated the posterior subregion of the dorsomedial striatum (pDMS) in acquisition and expression of action-outcome associations and in choosing actions that lead to rewarded locations. However, it is not clear whether the pDMS is involved in action selection based on an assessment of the efforts and outcomes of the available response options. Here we investigated in rats the effects of pDMS cell body lesions on effort-based decision making in a cost-benefit T-maze task. In this task, subjects could either choose to climb a barrier to obtain a high reward in one arm or a low reward in the other arm without a barrier. Furthermore, the effects of pDMS cell body lesions were examined in this task after a spatial alteration of reward allocation to analyze flexibility of choice behavior. Results revealed that choice behavior based on an assessment of cost-benefit ratios of the available response options was intact in rats with pDMS lesions. However, relative to sham controls, choice behavior in rats with pDMS lesions was less flexible after a spatial reversal of the high and low reward goal arm. Thus, in a T-maze task as used here, the pDMS may not support effort-related decision making, but flexibility of spatially guided behavior. (C) 2011 Elsevier B.V. All rights reserved.