Frontal white matter reductions in healthy males with complex stereotypies
Frontal white matter reductions in healthy males with complex stereotypies
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DOI：
10.1016/j.pediatrneurol.2004.09.005
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发表时间：
2005-02-01
影响因子：
3.8
通讯作者：
Singer, HS
中科院分区：
文献类型：
--
作者：
Kates, WR;Lanham, DC;Singer, HS
涉及手臂和手的刻板、双侧重复运动（复杂运动刻板）的病理生理机制尚不清楚。本研究采用容积磁共振成像技术比较了6名具有复杂刻板印象和平均智力的男性与年龄匹配的对照组的大脑叶和尾状核。结果表明，额叶白色物质以及左侧和右侧尾状核的体积减少，与大脑总白色体积不成比例。这些初步的数据表明，可能的功能障碍的皮质-纹状体-丘脑-皮质回路在儿童与非自闭症，生理运动刻板。(C)2005年，Elsevier Inc. All rights reserved.
The pathophysiologic mechanism for stereotypic, bilateral repetitive movements involving the arms and hands (complex motor stereotypies) is unknown. This study used volumetric magnetic resonance imaging to compare cerebral lobes and caudate nucleus in six males with complex stereotypies and average intelligence to age-matched control subjects. Results indicated volumetric reductions in frontal white matter, disproportionate to total cerebral white volume, and in the left and right caudate nuclei. These preliminary data suggest a possible dysfunction of cortico-striatal-thalamo-cortical circuitry in children with nonautistic, physiologic motor stereotypies. (C) 2005 by Elsevier Inc. All rights reserved.