ADRENAL ADENOCARCINOMA - A REVIEW OF 53 CASES
ADRENAL ADENOCARCINOMA - A REVIEW OF 53 CASES
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DOI：
10.1002/jso.2930550306
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发表时间：
1994-03-01
影响因子：
2.5
通讯作者：
HUBEN, RP
中科院分区：
文献类型：
--
作者：
ZOGRAFOS, GC;DRISCOLL, DL;HUBEN, RP
问题：对 53 名经组织学证实患有肾上腺癌的患者（30 名男性，23 名女性）进行了审查。十九（36%）有功能性肿瘤的内分泌表现。动脉造影阳性率为 95% (19/20)，CT 扫描阳性率为 94% (17/18)，超声检查阳性率为 92% (12/13)。 76% 的患者在诊断时处于 III 期和 IV 期。最常见的转移部位是肝脏、淋巴结、骨和肺。 39%的病例出现局部复发（15/38）。方法：41例患者接受了手术。 24例患者实现了全部肉眼肿瘤的完全手术切除。结果：总体中位生存时间为8个月，预计5年生存率为19%。不同分期的生存率（P = 0.01）以及肿瘤完全切除组与不完全切除组的生存率（P = 0.002）之间存在显着差异。结论：完整手术切除为局限性肾上腺癌提供了最佳的长期生存前景。 (C) 1994 年 Wiley-Liss 公司
Problem: Fifty-three patients (30 men, 23 women) with histologically proven adrenal carcinoma were reviewed. Nineteen (36%) had endocrine manifestations from functioning tumors. Arteriography was positive in 95% (19/20), CT scan in 94% (17/18), and ultrasound in 92% (12/13). Seventy-six percent of the patients, at the time of diagnosis, were stage III and IV. Most common metastatic sites were the liver, lymph nodes, bone, and lungs. Local recurrence developed in 39% of cases (15/38).Method: Forty-one patients underwent an operation. Complete surgical removal of all gross tumor was achieved in 24 patients.Result: The overall median survival time was 8 months, and the estimated 5-year survival rate 19%. There were significant differences in survival between the various stages (P = 0.01) and between the group of patients who underwent complete excision of the tumor and those with incomplete resection (P = 0.002).Conclusions: Complete surgical excision offers the best prospect for long-term survival in localized adrenal carcinoma. (C) 1994 Wiley-Liss, Inc.