Kinetics of virus-specific CD8+ T cells and the control of human immunodeficiency virus infection
Kinetics of virus-specific CD8+ T cells and the control of human immunodeficiency virus infection
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DOI：
10.1128/jvi.78.18.10096-10103.2004
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发表时间：
2004-09-01
影响因子：
5.4
通讯作者：
Perelson, AS
中科院分区：
文献类型：
--
作者：
Davenport, MP;Ribeiro, RM;Perelson, AS
几种灵长类动物模型表明，诱导细胞毒性T淋巴细胞的疫苗可能无法预防人类免疫缺陷病毒感染，但可能在控制病毒复制和延缓疾病进展方面具有长期益处。在此我们表明，对抗原特异性CD8(+) T细胞扩增动力学的分析显示，感染后激活延迟，使得早期病毒复制不受阻碍。在这个延迟阶段，对照组和接种疫苗组之间的病毒动力学没有差异。在感染后约第10天，病毒特异性CD8(+) T细胞数量增加，与此同时接种疫苗者的病毒复制减缓，病毒载量峰值降低约1个对数级。然而，这种反应太小且太迟，无法阻止持续性感染的建立。
Several primate models indicate that cytotoxic T lymphocyte-inducing vaccines may be unable to prevent human immunodeficiency virus infection but may have a long-term benefit in controlling viral replication and delaying disease progression. Here we show that analysis of the kinetics of antigen-specific CD8(+) T-cell expansion suggests a delay in activation following infection that allows unimpeded early viral replication. Viral kinetics do not differ between controls and vaccinees during this delay phase. An increase in virus-specific CD8(+) T-cell numbers around day 10 postinfection coincides with a slowing in viral replication in vaccinees and reduces peak viral loads by around I log. However, this response is too little too late to prevent establishment of persistent infection.