NEUROPEPTIDES IN THE CEREBRAL-CIRCULATION - RELEVANCE TO HEADACHE
NEUROPEPTIDES IN THE CEREBRAL-CIRCULATION - RELEVANCE TO HEADACHE
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DOI：
10.1046/j.1468-2982.1995.1504272.x
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发表时间：
1995-08-01
期刊：
影响因子：
4.9
通讯作者：
GOADSBY, PJ
中科院分区：
文献类型：
--
作者：
EDVINSSON, L;GOADSBY, PJ
本文简要介绍了含有神经肽Y （NPY）、血管活性肠肽（VIP）、P物质（SP）和降钙素基因相关肽（CGRP）的神经纤维对人脑循环的神经支配。用放射免疫法联合高效液相色谱法测定了人脑动脉内的神经肽。这些神经肽介导收缩（NPY）和扩张（VIP， SP， CGRP）。与偏头痛或丛集性头痛的自发性发作相结合，可以看到CGRP的释放。伴随鼻塞和鼻漏的相关症状，VIP被释放。成功的治疗可能中止肽的释放，同时头痛消失。
The article briefly describes the innervation of the human cerebral circulation by nerve fibers containing neuropeptide Y (NPY), vasoactive intestinal peptide (VIP), substance P (SP), and calcitonin gene-related peptide (CGRP). The neuropeptides in human cerebral arteries were characterized by radioimmunoassay in combination with HPLC. These neuropeptides mediate contraction (NPY) and dilatation (VIP, SP, CGRP). In conjunction with spontaneous attacks of migraine or cluster headache, release of CGRP is seen. With the associated symptoms of nasal congestion and rhinorrhea, VIP is released. Successful treatment may abort the peptide release in parallel with disappearance of headache.