Effect of growth hormone on human drug metabolism: time course and substrate specificity.
Effect of growth hormone on human drug metabolism: time course and substrate specificity.
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生长激素对人体药物代谢的影响：时间进程和底物特异性。
DOI：
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发表时间：
1980
期刊：
影响因子：
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通讯作者：
J. Perel
中科院分区：
文献类型：
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作者：
G. Redmond;J. Bell;P. Nichola;J. Perel
在缺乏儿童中，使用人生长激素（hGH）进行6周的替代治疗已被证明可显著延长异戊巴比妥t1/2。进行了确定这种效应的时间过程的研究，结果表明在治疗1 - 8天后没有变化或变化极小。6周时观察到的t1/2增加持续至少1年。与异戊巴比妥相比，发现茶碱在4名受试者中显示t1/2从平均7.52 +/- 4.44（SD）缩短至平均3.38 +/- 1.23小时。因此，hGH替代治疗导致这两种药物消除的数量大但相反的变化。然而，对于两种底物，hGH替代后的t1/2更接近于正常受试者报告的值。这表明hGH可能是体内药物消除的主要决定因素。
Replacement therapy for six weeks with human growth hormone (hGH) in deficient children has been shown to produce a significant lengthening of amobarbital t1/2. Studies to define the time course of this effect were carried out and indicate either no change or a minimal change after one to eight days of treatment. The increased t1/2 noted at six weeks persists for at least one year. In contrast to amobarbital, theophylline was found to exhibit a shortening of t1/2 from a mean of 7.52 +/- 4.44 (SD) to a mean of 3.38 +/- 1.23 hours in four subjects. Thus, replacement therapy with hGH results in quantitatively large but opposite changes in the elimination of these two drugs. For both substrates, however, t1/2 after hGH replacement more closely resembles values reported for normal subjects. This suggests that hGH may be a major determinant of in vivo drug elimination.