Role of interleukin-12 in primary influenza virus infection
Role of interleukin-12 in primary influenza virus infection
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DOI：
10.1128/jvi.72.6.4825-4831.1998
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发表时间：
1998-06-01
影响因子：
5.4
通讯作者：
Trinchieri, G
中科院分区：
文献类型：
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作者：
Monteiro, JM;Harvey, C;Trinchieri, G
研究了内源性白细胞介素-12 （IL-12）对BALB/c小鼠流感病毒免疫应答的影响。原发性流感病毒感染后，在肺中检测到IL-12 mRNA和蛋白，细胞因子诱导需要活病毒。内源性IL-12有助于NK细胞依赖性γ干扰素（ifn - γ）的早期产生（第3天和第5天），但不影响t细胞依赖性ifn - γ的晚期分泌（第7天）。IL-12有助于抑制早期病毒复制，但不是病毒清除所必需的。IL-12也适度地促进细胞毒性T淋巴细胞的激活。因此，在这个实验性流感病毒感染模型中，内源性IL-12主要参与先天免疫反应的早期发育和激活。
The effect of endogenous interleukin-12 (IL-12) on the influenza virus immune response in BALB/c mice was evaluated. Following primary influenza virus infection, IL-12 mRNA and protein are detected in the lung, with live virus being required for cytokine induction. Endogenous IL-12 contributes to early NK cell-dependent gamma interferon (IFN-gamma) production (days 3 and 5) but not late T-cell-dependent IFN-gamma secretion (day 7). IL-12 contributes to the inhibition of early virus replication but is not required for virus clearance. IL-12 also modestly contributes to the activation of cytotoxic T lymphocytes. Thus, in this model of experimental influenza virus infection, endogenous IL-12 contributes primarily to the early development and activation of the innate immune response.