Power Grid Protection of the Muscle Mitochondrial Reticulum.
Power Grid Protection of the Muscle Mitochondrial Reticulum.
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DOI：
10.1016/j.celrep.2017.03.063
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发表时间：
2017-04-18
期刊：
影响因子：
8.8
通讯作者：
Balaban RS
中科院分区：
文献类型：
--
作者：
Glancy B;Hartnell LM;Combs CA;Femnou A;Sun J;Murphy E;Subramaniam S;Balaban RS
线粒体网络连接使势能在整个细胞中快速通信和分配成为可能。然而，这种连通性使能量转换系统处于危险之中，因为损坏的元件可能危及整个网络。在这里，我们展示了心肌和骨骼肌（SKM）中线粒体网络保护的机制。我们发现，心肌线粒体网状结构被分割成由许多线粒体组成的子网络，这些线粒体通过高度特异性的线粒体连接点（IMJ）上丰富的接触位点连接在一起。在心脏和SKM子网络中，发生故障的线粒体的快速电和物理分离与IMJ的分离和伸长的线粒体收缩成浓缩结构一致。区域线粒体子网络限制了局部功能障碍的细胞影响，而受损线粒体的动态断开允许剩余线粒体在几秒钟内恢复正常功能。因此，线粒体网络安全性由横纹肌细胞中的主动和反应机制组成。
Mitochondrial network connectivity enables rapid communication and distribution of potential energy throughout the cell. However, this connectivity puts the energy conversion system at risk since damaged elements could jeopardize the entire network. Here we demonstrate the mechanisms for mitochondrial network protection in heart and skeletal muscle (SKM). We find that the cardiac mitochondrial reticulum is segmented into subnetworks comprised of many mitochondria linked through abundant contact sites at highly specific intermitochondrial junctions (IMJs). In both cardiac and SKM subnetworks, a rapid electrical and physical separation of malfunctioning mitochondria occurs consistent with detachment of IMJs and retraction of elongated mitochondria into condensed structures. Regional mitochondrial subnetworks limit the cellular impact of local dysfunction while the dynamic disconnection of damaged mitochondria allows the remaining mitochondria to resume normal function within seconds. Thus, mitochondrial network security is comprised of both proactive and reactive mechanisms in striated muscle cells.