HDAC6 a new cellular stress surveillance factor
HDAC6 a new cellular stress surveillance factor
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DOI：
10.4161/cc.7.1.5186
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发表时间：
2008-01-01
期刊：
影响因子：
4.3
通讯作者：
Khochbin, Saadi
中科院分区：
文献类型：
--
作者：
Matthias, Patrick;Yoshida, Minoru;Khochbin, Saadi
自HDAC6首次被鉴定并被认为是一种具有两个催化结构域的不寻常的组蛋白去乙酰化酶以来，已经过去了不到十年。早期证明其细胞质定位，其泛素结合和微管蛋白脱乙酰酶活性使HDAC6远离已知涉及其他组蛋白脱乙酰酶的一切。最近的发现证实了HDAC6在脱乙酰酶中的非常独特的功能，并指出这种蛋白质是细胞对细胞毒性攻击反应的主要调节剂。HDAC6既作为应激刺激的传感器，又作为效应器，由于其广泛的活动，介导和协调适当的细胞反应。
Less than a decade has passed since HDAC6 was first identified and regarded as an unusual histone deacetylase harbouring two catalytic domains. Early demonstration of its cytoplasmic localisation, its ubiquitin-binding and its tubulin-deacetylase activities took HDAC6 far away from everything known to involve other histone-deacetylases. Recent discoveries confirmed the very unique functions of HDAC6 among deacetylases and pointed to this protein as a master regulator of cell response to cytotoxic assaults. HDAC6 appears both as a sensor of stressful stimuli and as an effector, which, thanks to its wide range of activities, mediates and coordinates appropriate cell responses.