Shape-controlled production of biodegradable calcium alginate gel microparticles using a novel microfluidic device
Shape-controlled production of biodegradable calcium alginate gel microparticles using a novel microfluidic device
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DOI：
10.1021/la061729
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发表时间：
2006-10-24
期刊：
影响因子：
3.9
通讯作者：
Zhao, Xing-Zhong
中科院分区：
文献类型：
--
作者：
Liu, Kan;Ding, Hui-Jiang;Zhao, Xing-Zhong
在本文中，我们描述了一种在微流控装置中制备形状可控的海藻酸钙凝胶微粒的新方法。该微流控装置可以同时进行形状可控微球的制备和水凝胶微球的合成。这种由两个单独的流动聚焦通道和一个合成通道组成的新型微流控装置被成功地应用于连续微流控反应器，合成了尺寸和形状可控的凝胶微粒。通过基于微通道几何约束和液相流量的被动控制，我们成功地在微流控装置的聚焦流道中制备了形状多样的单分散海藻酸钠微粒(如塞状、圆盘状、微球状、棒状和线状)。海藻酸钠微粒的形状和大小可以通过调节不同水流的流速来调节。进一步的化学反应可以通过在合成通道中混合海藻酸钠微粒和氯化钙(CaCl2)溶液来启动。合成的海藻酸钙凝胶微球可以永久保持海藻酸钠微球的形状。研究了大小和形状可控的海藻酸钙微粒的制备条件及影响因素。
In this paper we describe a novel method of manufacturing shape-controlled calcium alginate gel microparticles in a microfluidic device. Both manufacturing shape-controlled microparticles and synthesizing hydrogel microparticles could be performed simultaneously in the microfluidic device. The novel microfluidic device comprised of two individual flow-focusing channels and a synthesizing channel was successfully applied as a continuous microfluidic reactor to synthesize gel microparticles with size and shape control. By passive control based on the microchannel geometric confinement and liquid-phase flow rates, we succeeded in producing monodisperse sodium alginate microparticles with diverse shapes (such as plugs, disks, microspheres, rods, and threads) in the flow-focusing channels of the microfluidic device. The shape and size of the sodium alginate microparticles could be tuned by adjusting the flow rates of the various streams. Further stages of the chemical reaction could be initiated by mixing sodium alginate microparticles and calcium chloride (CaCl2) solution in the synthesizing channel. The shapes of the sodium alginate microparticles could be permanently preserved by the synthesis of calcium alginate gel microparticles. The preparation conditions of size- and shape-controlled calcium alginate microparticles and influence factors were studied.