INCOMPLETE COMPENSATION OF CSF [H+] IN MAN DURING ACCLIMATIZATION TO HIGH-ALTITUDE (4,300 M)
INCOMPLETE COMPENSATION OF CSF [H+] IN MAN DURING ACCLIMATIZATION TO HIGH-ALTITUDE (4,300 M)
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DOI：
10.1152/jappl.1975.38.6.1067
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发表时间：
1975-01-01
影响因子：
3.3
通讯作者：
CHOSY, LW
中科院分区：
文献类型：
--
作者：
FORSTER, HV;DEMPSEY, JA;CHOSY, LW
本研究评估了 7 名健康男性在 250 m 海拔以及在 4,300 m 海拔停留 5 天和 10-11 天后动脉血和脑脊液酸碱状态的调节情况（PaO2 = 第 1 天 39 mmHg 至第 11 天 48 mmHg）。我们假设在这些相对稳态的条件下，观察到的腰椎脊髓液酸碱状态的变化与脑脊液中的变化平行。逗留期间的通气适应（第 11 天时为-14 mmHg PaCO2）伴随着：1）[HCO3-] 减少（-5 至 -7 meq/1），这在动脉血和脑脊液中是相似的； 2) 脑脊液和血液 pH 值的显着但不完全的补偿（70-75%）； 3) 脑脊液 pH 水平相对于含氧量正常的对照值保持显着碱性 (+0.05 +/- 0.01)。这些在 4,300 m 处的数据证实并扩展了我们之前关于更温和的慢性缺氧条件的发现。据推测，慢性缺氧和/或低碳酸血症期间脑脊液 pH 补偿的幅度和时间过程由血浆 [HCO2-] 的相应变化决定。
This study has assessed the regulation of arterial blood and cerebrospinal fluid acid-base status in seven healthy men, at 250 m altitude and after 5 and 10–11 days sojourn at 4,300 m altitude (PaO2 = 39 mmHg day 1 to 48 mmHg day 11). We assumed that observed changes in lumbar spinal fluid acid-base status paralleled those in cisternal CSF, under these relatively steady-state conditions. Ventilatory acclimatization during the sojourn (-14 mmHg PaCO2 at day 11) was accompanied by: 1) reductions in [HCO3-] (-5 to -7 meq/1) which were similar in arterial blood and CSF; 2) substantial, yet incomplete, compensation (70–75%) of both CSF and blood pH; and 3) a level of CSF pH which was maintained significantly alkaline (+0.05 +/- 0.01) to normoxic control values. These data at 4,300 m confirmed and extended our previous findings for more moderate conditions of chronic hypoxia. It was postulated that the magnitude and time course of pH compensation in the CSF during chronic hypoxia and/or hypocapnia are determined by corresponding changes in plasma [HCO2-].