Conformational studies of two isomeric ring-expanded purine nucleosides and their 5'-mono- and -diphosphate derivatives.
Conformational studies of two isomeric ring-expanded purine nucleosides and their 5'-mono- and -diphosphate derivatives.
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两种异构扩环嘌呤核苷及其 5-单磷酸和二磷酸衍生物的构象研究。
DOI：
10.1016/0006-291x(89)91040-1
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发表时间：
1989
影响因子：
3.1
通讯作者：
Bhan,A
中科院分区：
文献类型：
--
作者：
Hosmane,RS;Bhan,A
摘要核苷Ia和IIa分别以正构象和反构象存在于固体和溶液中。化合物Ia在转化为相应的5‘-一和二磷酸衍生物时发生了显著的构象变化，伴随着反构象的增加，而IIa的构象在核苷和核苷酸之间保持合理的恒定。Ia具有C2‘-endo C3’-exo构型，而IIa具有相反的C2‘-exo-C3’-endo构象。两个核苷的C5‘分别具有轴向构象和赤道构象。
Abstract The nucleosides Ia and IIa exist in syn and anti conformations, respectively, both in solid state and solution. Compound Ia undergoes significant conformational change, accompanied by increased population of the anti conformer, upon conversion to the corresponding 5′-mono-and-diphosphate derivatives, whereas conformation of IIa remains reasonably constant between nucleoside and nucleotides. While Ia possessed the C2′-endo C 3′-exo geometry, IIa had the opposite C 2′-exo-C 3′-endo conformation. The C5′ of the two nucleosides bore axial and equatorial conformations, respectively.