GADOLINIUM-LABELED LIPOSOMES CONTAINING AMPHIPHILIC GD-DTPA DERIVATIVES OF VARYING CHAIN-LENGTH - TARGETED MRI CONTRAST ENHANCEMENT AGENTS FOR THE LIVER
GADOLINIUM-LABELED LIPOSOMES CONTAINING AMPHIPHILIC GD-DTPA DERIVATIVES OF VARYING CHAIN-LENGTH - TARGETED MRI CONTRAST ENHANCEMENT AGENTS FOR THE LIVER
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DOI：
10.1016/0730-725x(91)90425-l
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发表时间：
1991-01-01
影响因子：
2.5
通讯作者：
HUANG, L
中科院分区：
文献类型：
--
作者：
KABALKA, GW;DAVIS, MA;HUANG, L
合成了顺磁性脂质体造影剂，并将其用于正常Balb/c小鼠肝脏T1MR成像的选择性增强。模拟磷脂的两亲性格拉络合物被引入到小单层脂质体(SUV)的薄层中，使其成为其表面不可分割的一部分。两亲性络合剂由DTPA试剂组成，其中一对不同长度的烷基链通过酰胺键连接在一起。两亲性试剂的体内寿命与烷基的链长有关。
Paramagnetic liposomal contrast agents were synthesized and utilized for selective augmentation of T1 MR imaging of the livers of normal Balb/c mice. Amphiphilic gadolinium complexes, which mimic phospholipids, were incorporated into the lamella of small unilamellar liposomes (SUV) such that they become an integral part of its surface. The amphiphilic complexing agents consisted of DTPA reagents in which a pair of alkyl chains of varying lengths are attached via amide linkages. The in vivo lifetimes of the amphiphilic agents were found to be dependent on the chain length of the alkyl groups.