Cytotoxic sesquiterpenoids from Sarcandra glabra
Cytotoxic sesquiterpenoids from Sarcandra glabra
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DOI：
10.1016/j.tet.2012.11.023
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发表时间：
2013-01-14
期刊：
影响因子：
2.1
通讯作者：
Yue, Jian-Min
中科院分区：
文献类型：
--
作者：
Ni, Gang;Zhang, Hua;Yue, Jian-Min
从草珊瑚全草中分离得到5个新的倍半萜二聚体化合物，即肉珊瑚内酯F-J（1-5），3个新的倍半萜单体化合物（6-8），14个已知的倍半萜化合物。用CD激子手性方法确定了化合物1-5的绝对构型。化合物1代表在C-5处带有氢过氧基的茚烷型倍半萜二聚体的第一个实例。化合物1和3对HL-60细胞系表现出细胞毒性，IC 50值分别为0.03和1.2 μ M。(c)2012爱思唯尔有限公司保留所有权利。
Five new sesquiterpenoid dimers, sarcandrolides F-J (1-5), three new sesquiterpenoid monomers (6-8), and 14 known sesquiterpenoids, were isolated from the whole plants of Sarcandra glabra. The absolute configurations of compounds 1-5 were established by the CD exciton chirality method. Compound 1 represents the first example of a lindenane-type sesquiterpenoid dimer bearing a hydroperoxy group at C-5. Compounds 1 and 3 exhibited cytotoxicity against the HL-60 cell line with IC50 values of 0.03 and 1.2 mu M, respectively. (c) 2012 Elsevier Ltd. All rights reserved.