Flexible ex vivo phantoms for validation of diffusion tensor tractography on a clinical scanner.
Flexible ex vivo phantoms for validation of diffusion tensor tractography on a clinical scanner.
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DOI：
10.1007/s11604-006-0076-4
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发表时间：
2006-11-01
影响因子：
--
通讯作者：
Ohtomo, Kuni
中科院分区：
文献类型：
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作者：
Watanabe, Makoto;Aoki, Shigeki;Ohtomo, Kuni
目得：本研究的目的是开发离体扩散张量（DT）的灵活phanasthene.MATERIALS和METHODS：材料的棉花，单丝尼龙，人造丝，聚酯束与螺旋缠绕带和浸泡在水中的纺织线束。在1.5特斯拉临床磁共振扫描仪上使用具有15个运动探测梯度方向的回波平面成像序列采集DT图像。DT纤维束成像与播种和线跟踪方法进行了最初开发的软件在基于PC的workstation.Results：我们观察到相对较高的分数各向异性的聚酯模体，并能够重建纤维束成像。当束呈线性排列时，显示沿束沿着的直线束。纤维束易于弯曲或在一端分叉;无论是弯曲还是分支，纤维束都遵循纤维束的路线，与直接目视观察一致。结论：聚酯纤维体模具有弥散各向异性结构，在相同条件下可重复使用，不同于活体中枢神经系统。这将有助于验证DT序列和优化DT纤维束成像软件的算法或参数。此外，模型的灵活性将使我们能够模拟人类轴突投射。
PURPOSE: The aim of this study was to develop ex vivo diffusion tensor (DT) flexible phantoms.MATERIALS AND METHODS: Materials were bundles of textile threads of cotton, monofilament nylon, rayon, and polyester bunched with spiral wrapping bands and immersed in water. DT images were acquired on a 1.5-Tesla clinical magnetic resonance scanner using echo planar imaging sequences with 15 motion probing gradient directions. DT tractography with seeding and a line-tracking method was carried out by software originally developed on a PC-based workstation.RESULTS: We observed relatively high fractional anisotropy on the polyester phantom and were able to reconstruct tractography. Straight tracts along the bundle were displayed when it was arranged linearly. It was easy to bend arcuately or bifurcate at one end; and tracts followed the course of the bundle, whether it was curved or branched and had good agreement with direct visual observation. Tractography with the other fibers was unsuccessful.CONCLUSION: The polyester phantom revealed a diffusion anisotropic structure according to its shape and would be utilizable repeatedly under the same conditions, differently from living central neuronal system. It would be useful to validate DT sequences and to optimize an algorithm or parameters of DT tractography software. Additionally, the flexibility of the phantom would enable us to model human axonal projections.