19F-MRT der Lungenventilation in Atemanhaltetechnik mittels SF6-Gas
19F-MRT der Lungenventilation in Atemanhaltetechnik mittels SF6-Gas
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Atemanhaltetechnik mittels SF6 气体中的 19F-MRT 肺部通风
DOI：
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发表时间：
2000
期刊：
影响因子：
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通讯作者：
H. Kauczor
中科院分区：
文献类型：
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作者：
W. Schreiber;K. Markstaller;N. Weiler;B. Eberle;S. Laukemper;A. Scholz;K. Bürger;M. Thelen;H. Kauczor
屏气19 F-磁共振成像肺通气使用SF6气体。目的：建立一种用19 F磁共振成像（MRI）分析屏气状态下吸入SF6气体肺通气的方法。材料和方法：使用Siemens Magnetom Vision 1.5T扫描仪，使用常规梯度回波进行测量。使用TR/TE/α = 1.4 ms/ 0.48 ms/40°的超快梯度回波脉冲序列采集肺冠状面图像，无切片选择。在NEX = 200平均值和MA = 32 × 64原始数据矩阵的情况下，采集时间为9 s/图像。在三维脉冲序列（TR/TE/ α = 1.6ms/0.48ms/65°，NEX = 20）运行49 s时，获得了4.7 × 6.3 × 15 mm 3的较高空间分辨率。在三只麻醉和通气的猪（18 kg）中进行测量。结果：SF6浓度与19 F信号强度呈近似线性关系.在没有切片选择的情况下获得的图像中的信噪比为30.9，在切片选择的情况下为14.9。在动物中未观察到SF 6分布到两个肺之间的差异。结论：屏气MRI首次显示了SF6气体在肺内的分布.通过高度重复的信号平均来补偿低自旋密度。屏气19 F-MR成像的通风的空气空间，以评估SF 6在人肺中的分布似乎是一个有趣的新方法，它可以实现很少的技术努力，并不依赖于放射性同位素。
Breathhold 19 F-Magnetic Resonance Imaging of Lung Ventilation using SF 6 Gas. Objective: Development of a method to analyze lung ventilation by 19 F-magnetic resonance imaging (MRI) of inspired SF 6 gas during breathhold. Material and Methods: Measurements were performed with a Siemens Magnetom Vision 1.5T scanner using the conventional gradient overdrive. Coronal images of the lung were acquired using ultrafast gradient-echo pulse sequences with TR/TE/α = 1.4 ms/ 0.48 ms/40° without slice selection. With NEX = 200 averages and MA = 32 × 64 raw data matrix, the acquisition time was 9s/image. Higher spatial resolution of 4.7 × 6.3 × 15 mm 3 was obtained with a three-dimensional pulse sequence (TR/TE/ α = 1.6 ms/0.48 ms/65°, NEX = 20) running for 49 s. Measurements wer performed in three anesthetized and ventilated pigs (18 kg). Results: A nearly linear relation between SF 6 concentration and 19 F signal intensity was observed. The signal-to-noise ratio in images obtained without slice selection was 30.9, with slice selection it was 14.9. No differences between SF 6 distribution to both lungs were observed in the animals. Conclusion: Breathhold MRI of SF 6 gas distribution in the lung was demonstrated for the first time. The low spin-density was compensated for by highly repetitive signal averaging. Breathhold 19 F-MR imaging of ventilated airspaces to assess SF 6 distribution in the human lung appears to be an interesting new method, which can be implemented with little technical efforts, and does not rely on radioactive isotopes.