Combined effects of acute, very-low-dose ethanol and delta(9)-tetrahydrocannabinol in healthy human volunteers
Combined effects of acute, very-low-dose ethanol and delta(9)-tetrahydrocannabinol in healthy human volunteers
复制标题
DOI：
10.1016/j.pbb.2010.11.013
复制
发表时间：
2011-02-01
影响因子：
3.6
通讯作者：
de Wit, Harriet
中科院分区：
文献类型：
--
作者：
Ballard, Michael E.;de Wit, Harriet
基本原理：以前的研究检查了乙醇和大麻或其主要精神活性成分Delta（9）-四氢大麻酚（THC）的综合作用，结果好坏参半。一项体外研究的数据表明，这些药物的联合亚阈值剂量可能相互作用，产生协同效应。非常低剂量的两种药物组合尚未在human.Materials和方法：本研究评估急性，非常低剂量的乙醇和THC的组合是否产生协同作用的主观，认知和生理措施。健康志愿者（n = 11）接受含有安慰剂或THC（2.5 mg）的胶囊，和含有安慰剂或乙醇（0.1和0.2 g/kg）的饮料，单独和联合，在不同的阶段，在受试者内，随机，双盲设计。在每次会议期间，参与者完成了工作记忆，心理能力和简单反应时间的测量，并提供了主观情绪和药物效果评级。心血管措施，定期intervention.Results：预期的，单独给药时，这些非常低剂量的乙醇和THC只有中度影响孤立的措施。这些药物的联合作用是没有协同作用，在某些情况下，似乎是小于additional.Conclusions：我们的数据提供了没有证据的协同作用的急性组合非常低剂量的乙醇和THC的主观或生理反应，或认知性能。(C)2010年爱思唯尔公司All rights reserved.
Rationale: Previous studies examining the combined effects of ethanol and cannabis, or its primary psychoactive ingredient, Delta(9)-tetrahydrocannabinol (THC), have provided mixed results. Data from an in vitro study suggests that combined, sub-threshold doses of these drugs may interact to produce synergistic effects. Very low doses of the two drugs in combination have not been tested in humans.Materials and methods: This study assessed whether combinations of acute, very low doses of ethanol and THC produce synergistic effects on subjective, cognitive, and physiological measures. Healthy volunteers (n = 11) received capsules containing placebo or THC (2.5 mg), and beverages containing placebo or ethanol (0.1 and 0.2 g/kg) alone, and in combination, across separate sessions, in a within-subjects, randomized, double-blind design. During each session, participants completed measures of working memory, psychomotor ability, and simple reaction time, and provided subjective mood and drug effect ratings. Cardiovascular measures were obtained at regular intervals.Results: As intended, when administered alone, these very low doses of ethanol and THC had only moderate effects on isolated measures. The combined effects of these drugs were not synergistic, and in some cases appeared to be less-than-additive.Conclusions: Our data provide no evidence for synergistic effects of acute combinations of very-low-dose ethanol and THC on subjective or physiologic response, or on cognitive performance. (C) 2010 Elsevier Inc. All rights reserved.