Sleep and quantitative EEG in patients with progressive supranuclear palsy
Sleep and quantitative EEG in patients with progressive supranuclear palsy
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DOI：
10.1212/wnl.49.4.999
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发表时间：
1997-10-01
期刊：
影响因子：
9.9
通讯作者：
Gauthier, S
中科院分区：
文献类型：
--
作者：
Montplaisir, J;Petit, D;Gauthier, S
对6例进行性核上性麻痹（PSP）患者（平均年龄70.5岁）的睡眠结构和清醒和REM睡眠的定量EEG进行了研究，并与6例对照组（平均年龄69.8岁）进行了比较。特别注意的是定量REM睡眠变量，因为已知的PSP相关退化的脚桥脑被盖（PPT）-一个关键的结构，在REM睡眠的产生。PSP患者的总睡眠时间较短，睡眠效率较低，睡眠纺锤波急剧减少，无张力慢波睡眠和REM睡眠百分比较低。快速眼动睡眠的百分比较低是由于快速眼动期的数量减少和平均持续时间减少的结果。REM密度也降低，而REM效率，张力不足，和相位EMG与对照值相似。REM睡眠的发现与PPT在REM睡眠诱导中的已知作用一致。PSP患者的6个额叶导联和C4、P4和T4的清醒EEG减慢。清醒状态下额叶脑电图减慢与影像学和神经心理学研究结果雅阁，显示这些患者额叶受损。REM睡眠EEG在任何区域都没有明显变慢。由于以前所有关于PSP的研究都依赖于EEG描记的视觉检查，因此目前发现的额叶EEG减慢（而不是颞区或弥漫性）表明，我们的定量EEG方法在确定受损皮层活动的特定区域方面可能更有用。
Sleep architecture and quantitative EEG from wakefulness and REM sleep were studied in six patients (mean age, 70.5 years) with progressive supranuclear palsy (PSP) and compared with that of six control subjects (mean age, 69.8 years). Particular attention was given to quantifying REM sleep variables because of the known PSP-associated degeneration of the pedunculopontine tegmentum (PPT)-a critical structure in REM sleep generation. Patients with PSP had a shorter total sleep time, a lower sleep efficiency, a drastic reduction in sleep spindles, an atonic slow-wave sleep, and a lower percentage of REM sleep. The lower percentage of REM sleep was the result of both a reduction in the number of REM periods and a reduction in mean period of duration. REM density was also reduced while REM efficiency, atonia, and phasic EMG were similar to control values. REM sleep findings are consistent with the known role of the PPT in REM sleep induction. A slowing of the awake EEG was found for the six frontal leads and for C4, P4, and T4 in PSP patients. The frontal EEG slowing found in wakefulness is in accord with imaging and neuropsychological studies showing impairment of the frontal lobes in these patients. REM sleep EEG was not significantly slower in any regions. Because all previous studies on PSP have relied on visual inspection of the EEG tracings, the present finding of EEG slowing in the frontal lobes (rather than in the temporal regions or diffusely) suggests that our quantitative EEG approach may be more useful in determining specific regions of impaired cortical activity.