Propranolol hydrochloride release behaviour of crosslinked chitosan membranes.
Propranolol hydrochloride release behaviour of crosslinked chitosan membranes.
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DOI：
10.1002/jctb.280580211
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发表时间：
2007-04
影响因子：
3.4
通讯作者：
D. Thacharodi;K. Rao
中科院分区：
文献类型：
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作者：
D. Thacharodi;K. Rao
采用溶剂蒸发法制备了20微米厚度的壳聚糖膜，并与不同浓度的戊二醛交联，得到了不同交联程度的膜。这些膜通过热重（TG）分析、差示扫描量热法（DSC）和拉伸强度研究进行了表征。通过在静态玻璃扩散池中进行渗透性研究，评价了交联对盐酸心得安膜渗透性的影响。壳聚糖膜的热稳定性因交联而降低。通过交联提高了膜的抗拉强度。膜内交联点的引入降低了其对盐酸心得安的渗透性，其渗透性和扩散系数均有所下降。渗透性研究揭示了亲水剂如盐酸心得安通过壳聚糖和交联壳聚糖膜的孔隙机制。
Chitosan membranes of 20 microns thickness were prepared by a solvent evaporation technique and crosslinked with different concentrations of glutaraldehyde to obtain membranes of various degrees of crosslinking. These membranes were characterized by thermogravimetric (TG) analysis, differential scanning calorimetry (DSC) and tensile strength studies. The effect of crosslinking on the permeability of membranes to propranolol hydrochloride was evaluated by permeation studies conducted in static glass diffusion cells. A decrease in the thermal stability of chitosan membranes due to crosslinking was observed. The tensile strength of the membranes was improved by crosslinking. The introduction of crosslink points within the membrane reduced its permeability to propranolol hydrochloride as evidenced by decreased permeability and diffusion coefficients. Permeability studies revealed the operation of a pore mechanism in the transport of hydrophilic agents such as propranolol hydrochloride through chitosan and crosslinked chitosan membranes.