Epidemiology of vestibulo-ocular reflex function: data from the Baltimore Longitudinal Study of Aging.
Epidemiology of vestibulo-ocular reflex function: data from the Baltimore Longitudinal Study of Aging.
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DOI：
10.1097/mao.0000000000000610
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发表时间：
2015-02
期刊：
影响因子：
--
通讯作者：
Agrawal Y
中科院分区：
文献类型：
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作者：
Li C;Layman AJ;Geary R;Anson E;Carey JP;Ferrucci L;Agrawal Y
确定社区居住成人前庭眼反射（VOR）功能的年龄相关变化，并评估这些变化与人口统计学特征和心血管危险因素的相关性。巴尔的摩老龄化纵向研究（BLSA）中的横断面分析，这是一项纵向前瞻性队列研究。急诊教学医院内的前庭测试实验室。在BLSA注册的社区居住成年人。用视频头脉冲测试和视敏度测试进行水平VOR增益测量。VOR增益计算为眼速度与头速度的比值。通过研究问卷收集人口统计学和心血管危险因素数据。对109例受试者进行了分析，平均年龄（SD）为69.9岁（14.2岁），范围为26 - 92岁。在校正分析中，VOR增益从26岁至79岁保持稳定，之后以0.012/年的速率显著下降（p = 0.033）。在多变量模型中，年龄≥ 80岁的个体VOR增益小于0.80的几率相对于年龄<80岁的个体增加近8倍（患病率为13.2% vs. 2.8%; OR 7.79，95%CI：1.04-58.38）。除此之外，VOR增益在人口统计学或心血管风险组之间没有显著差异。我们报告年龄相关的VOR功能下降的个人年龄在80岁及以上。进一步的分析正在进行中，以确定这些VOR异常对老年人功能和活动结果的重要性。
To determine age-related changes in vestibulo-ocular reflex (VOR) function in community-dwelling adults, and evaluate these for associations with demographic characteristics and cardiovascular risk factors. Cross-sectional analysis within the Baltimore Longitudinal Study of Aging (BLSA), a longitudinal prospective cohort study. Vestibular testing laboratory within an acute care teaching hospital. Community-dwelling adults enrolled in the BLSA. Horizontal VOR gain measurement using video head-impulse testing and visual acuity testing. VOR gain was calculated as the ratio of eye velocity to head velocity. Demographic and cardiovascular risk factor data were collected through study questionnaires. One hundred nine subjects were analyzed with mean age (SD) 69.9 years (14.2), with a range from 26 to 92 years. VOR gain remained stable from age 26 to 79 after which it significantly declined at a rate of 0.012/year (p = 0.033) in adjusted analyses. Individuals aged 80 years or older had a nearly 8-fold increased odds of VOR gain less than 0.80 relative to those aged less than 80 years in multivariate models (prevalence of 13.2% vs. 2.8%; OR 7.79, 95% CI: 1.04–58.38). Otherwise, VOR gain did not differ significantly across demographic or cardiovascular risk groups. We report age-related decline in VOR function in individuals aged 80 years and older. Further analyses are in progress to establish the significance of these VOR abnormalities to functional and mobility outcomes in older individuals.