Understanding exogenous factors and biological mechanisms for cognitive frailty: a multidisciplinary scoping review
Understanding exogenous factors and biological mechanisms for cognitive frailty: a multidisciplinary scoping review
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了解认知脆弱的外源因素和生物机制：多学科范围审查
DOI：
10.1101/2024.01.18.24301491
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发表时间：
2024
期刊：
影响因子：
--
通讯作者：
Holland C
中科院分区：
文献类型：
--
作者：
Holland C
认知脆弱（CF）是不伴有痴呆的认知障碍和身体虚弱的结合。虽然每个元素的预测因子都得到了很好的研究，但它们共同出现的机制尚未整合，特别是在社会，心理和生物因素之间的关系方面。这一跨学科的范围审查着手对异质性多学科文献进行分类，以确定CF的潜在途径和机制以及研究差距。如果研究使用了CF的定义，或者集中在认知障碍和虚弱的结合（通过任何措施），并且排除了关于特定疾病人群，干预措施，流行病学或死亡率预测的研究，则纳入研究。检索词包括“认知脆弱”或（（“认知下降”或“认知障碍”）和（脆弱 *）），以及引出机制、预测因子、原因、途径和风险因素的术语。为确保纳入动物和细胞模型，添加了“行为”或“认知衰退”或“衰老”等关键词。共收录论文206篇。描述性分析提供了从社会和环境到心理到生物的高层次的决定因素分类。模式区分CF从阿尔茨海默氏病和社会和心理的主持人和调解人的基础生物和生理变化和CF发展的轨迹，建议作为进一步研究的重点。
Cognitive frailty (CF) is the conjunction of cognitive impairment without dementia and physical frailty. While predictors of each element are well-researched, mechanisms of their co-occurrence have not been integrated, particularly in terms of relationships between social, psychological, and biological factors. This interdisciplinary scoping review set out to categorise a heterogenous multidisciplinary literature to identify potential pathways and mechanisms of CF, and research gaps. Studies were included if they used the definition of CF OR focused on conjunction of cognitive impairment and frailty (by any measure), AND excluded studies on specific disease populations, interventions, epidemiology or prediction of mortality.Searches used Web of Science, PubMed and Science Direct. Search terms included “cognitive frailty” OR ((“cognitive decline” OR “cognitive impairment”) AND (frail*)), with terms to elicit mechanisms, predictors, causes, pathways and risk factors. To ensure inclusion of animal and cell models, keywords such as “behavioural” or “cognitive decline” or “senescence”, were added. 206 papers were included. Descriptive analysis provided high-level categorisation of determinants from social and environmental through psychological to biological. Patterns distinguishing CF from Alzheimer’s disease were identified and social and psychological moderators and mediators of underlying biological and physiological changes and of trajectories of CF development were suggested as foci for further research.