Total cerebral blood flow in relation to cognitive function: The Rotterdam Scan Study
Total cerebral blood flow in relation to cognitive function: The Rotterdam Scan Study
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DOI：
10.1038/jcbfm.2008.62
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发表时间：
2008-10-01
影响因子：
6.3
通讯作者：
Breteler, Monique M. B.
中科院分区：
文献类型：
--
作者：
Poels, Marielle M. F.;Ikram, Mohammad Arfan;Breteler, Monique M. B.
大脑灌流不足与认知功能较差有关。我们调查了脑血流和认知之间的联系，以及这种联系是否独立于脑容量。鹿特丹扫描研究以人群为基础，在892名年龄在60岁到91岁之间的参与者中，我们使用磁共振成像测量了总脑血流量(TCBF)和脑体积。较低的tCBF与较差的信息处理速度、执行功能和全局认知有关。然而，在对脑容量进行tCBF校正后，这些关联消失了。TCBF和认知之间的联系可能通过脑萎缩来调节或混淆。未来对tCBF的研究应考虑脑萎缩。
Cerebral hypoperfusion has been associated with worse cognitive function. We investigated the association between cerebral blood flow and cognition and whether this association is independent of brain volume. In 892 participants, aged 60 to 91 years, of the population-based Rotterdam Scan study, we measured total cerebral blood flow (tCBF) and brain volume using magnetic resonance imaging. Lower tCBF was associated with worse information-processing speed, executive function, and global cognition. However, after correcting tCBF for brain volume, these associations disappeared. The association between tCBF and cognition may be mediated or confounded by brain atrophy. Future studies on tCBF should take into account brain atrophy.