A receiver operating: Characteristic partial area index for highly sensitive diagnostic tests
A receiver operating: Characteristic partial area index for highly sensitive diagnostic tests
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DOI：
10.1148/radiology.201.3.8939225
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发表时间：
1996-12-01
期刊：
影响因子：
19.7
通讯作者：
Nishikawa, RM
中科院分区：
文献类型：
--
作者：
Jiang, YL;Metz, CE;Nishikawa, RM
目的：受试者工作特征(ROC)曲线下面积(A(Z))被广泛用作诊断性能的指标。然而，当临床上必须保持高灵敏度时，A(Z)并不是对临床诊断表现的有意义的总结。作者开发了一种新的ROC部分面积指数，它在这种情况下更有意义地衡量临床诊断性能，以总结仅在高敏感区域的ROC曲线。材料和方法：从传统的双正态模型推导出部分面积指数的数学公式。这一指标明显差异的统计检验公式类似于A(Z)的公式。结果：以乳腺X光摄影为例，说明了局部面积指数在测量临床诊断性能方面比A(Z)更有意义的情况。结论：局部面积指数可以作为高灵敏度诊断试验中传统A(Z)指数的更有意义的替代。
PURPOSE: Area under a receiver operating characteristic (ROC) curve (A(z)) is widely used as an index of diagnostic performance. However, A(z) is not a meaningful summary of clinical diagnostic performance when high sensitivity must be maintained clinically. The authors developed a new ROC partial area index, which measures clinical diagnostic performance more meaningfully in such situations, to summarize an ROC curve in only a high-sensitivity region.MATERIALS AND METHODS: The mathematical formulation of the partial area index was derived from the conventional binormal model. Statistical tests of apparent differences in this index were formulated analogous to that of A(z). One common statistical test involving the partial area index was validated by computer simulations under realistic conditions.RESULTS: An example in mammography illustrates a situation in which the partial area index is more meaningful than A(z) in measuring clinical diagnostic performance.CONCLUSION: The partial area index can be used as a more meaningful alternative to the conventional A(z) index for highly sensitive diagnostic tests.