Sex- and gender-associated clinical and psychosocial characteristics of patients with psoriasis
Sex- and gender-associated clinical and psychosocial characteristics of patients with psoriasis
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DOI：
10.1111/ced.14218
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发表时间：
2020-05-18
影响因子：
4.1
通讯作者：
Abeni, D.
中科院分区：
文献类型：
--
作者：
Napolitano, M.;Mastroeni, S.;Abeni, D.
性别和社会性别可能影响疾病的流行、不良反应和对治疗的反应。目的分析银屑病门诊患者的性别差异。方法在罗马IDI-IRCCS进行了为期3年的横断面研究。总共有3023名牛皮癣患者被纳入研究。记录了人体测量学和人口统计学特征，皮肤科医生评估了疾病的临床严重程度。收集生活质量（QoL）问卷。进行单因素和多因素分析以检查与性别相关的因素。结果我们发现在临床特征、疾病严重程度、心理困扰和生活质量方面存在性别和性别相关的差异。男性与体重指数、吸烟、饮酒、牛皮癣严重程度指数>= 10和发病年龄>= 20岁相关。女性与糖尿病家族史、关节受累、非弥漫性斑块型银屑病的临床类型、较高的心理困扰和对生活质量的影响较大相关。结论本研究确定了银屑病的潜在临床相关性的性别差异。
Background Sex and gender may affect disease prevalence, adverse effects and response to therapy.Aim To analyse sex and gender differences in outpatients with psoriasis.Methods A cross-sectional study was conducted at IDI-IRCCS, Rome, over a 3-year period. In total, 3023 patients with psoriasis were enrolled. Anthropometric and demographic characteristics were recorded, and a dermatologist evaluated the clinical severity of disease. Quality of life (QoL) questionnaires were collected. Univariate and multivariate analyses were performed to examine factors associated with sex.Results We found sex- and gender-associated differences in clinical characteristics, disease severity, psychological distress and quality of life. Male sex was associated with body mass index, smoking, alcohol consumption, Psoriasis Area Severity Index >= 10 and age at onset >= 20 years. Female sex was associated with family history of diabetes, joint involvement, clinical type other than diffuse plaque psoriasis, higher psychological distress and a greater effect on QoL.Conclusion Our study identified sex and gender differences of potential clinical relevance in psoriasis.