Serum adiponectin and leptin levels in psoriatic patients according to topical treatment
Serum adiponectin and leptin levels in psoriatic patients according to topical treatment
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DOI：
10.3109/09546634.2014.915917
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发表时间：
2015-04-01
影响因子：
2.9
通讯作者：
Swiderska, M.
中科院分区：
文献类型：
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作者：
Baran, A.;Flisiak, I.;Swiderska, M.
目的：银屑病被认为是一种与肥胖、心血管疾病和代谢综合征相关的全身性疾病。脂肪因子对许多代谢过程有影响。本研究的目的是评估常规外用治疗对银屑病患者血清脂联素和瘦素水平的影响。方法：对49例斑块型银屑病复发患者和16例健康对照者进行检测。在治疗前和应用14天后收集血液样品。血清脂联素和瘦素的浓度进行了检查，通过酶联免疫吸附试验的相关性与有效的局部treatment.Results：脂联素和瘦素血清水平显着降低银屑病患者相比，对照组。作为局部治疗的结果，血清脂联素水平没有显著变化。血清瘦素水平显著升高，但仍低于对照组。结论：瘦素可能是银屑病疗效评价的一个有用指标。
Objectives: Psoriasis has been considered as a systemic disease associated with obesity, cardiovascular diseases and metabolic syndrome. Adipokines have influence on many metabolic processes. Aim of this study was to evaluate the effect of conventional topical treatment on serum adiponectin and leptin levels in patients with psoriasis.Methods: Forty-nine patients with relapse of plaque-type psoriasis and 16 healthy controls were examined. Blood samples were collected before therapy and after 14 days of application. Serum adiponectin and leptin concentrations were examined by enzyme-linked immunosorbent assay for correlations with effectiveness of topical treatment.Results: Adiponectin and leptin serum levels were significantly decreased in psoriatic patients in comparison to the controls. As a result of the topical treatment, serum adiponectin level did not significantly change. Serum leptin level increased significantly, still remaining lower than in the controls.Conclusions: Leptin might be a useful marker in assessing the efficacy of the treatment for psoriasis.