Tumor targeted, stealthy and degradable bismuth nanoparticles for enhanced X-ray radiation therapy of breast cancer
Tumor targeted, stealthy and degradable bismuth nanoparticles for enhanced X-ray radiation therapy of breast cancer
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DOI：
10.1016/j.biomaterials.2017.10.048
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发表时间：
2018-02-01
期刊：
影响因子：
14
通讯作者：
Su, Ming
中科院分区：
文献类型：
--
作者：
Deng, Junjie;Xu, Shandong;Su, Ming
重元素纳米粒子可以作为放射增敏剂来增强x射线放射治疗，但将纳米粒子放射增敏剂转化为临床癌症治疗的一个主要障碍是纳米粒子的不可降解性，这可能导致体内积聚和长期毒性。本文报道了一种插入叶酸的红细胞膜修饰铋纳米粒子（即F-RBC铋纳米粒子）在乳腺癌x射线放射治疗中的应用，其中细胞膜涂层提供了较长的血液循环时间，叶酸作为肿瘤靶向剂，x射线与铋纳米粒子相互作用产生更多自由基对癌细胞的损伤，生理条件有助于治疗后铋纳米粒子的溶解。当使用F-RBC铋纳米粒子致敏x射线辐射时，证实了小鼠的肿瘤抑制作用和生存率的提高。体内生物分布和组织学分析表明，F-RBC铋纳米颗粒在15天后从动物体内排出，主要器官未见明显损伤或炎症。铋纳米粒子在体内的细胞膜修饰和溶解使循环、辐射增强和体内清除的微调得以实现，从而使治疗效果最大化，使长期毒性最小化。(c) 2017 Elsevier Ltd.版权所有。
Nanoparticles of heavy elements can be used as radiosensitizers to enhance X-ray radiation therapy, but a major roadblock in translating nanoparticle radiosensitizers into clinical practice of cancer treatment is related to the non-degradable nature of the nanoparrtcles, which can cause accumulation inside body and long-term toxicity. This paper reports the use of a folate-inserted, red blood cell membrane-modified bismuth (i.e., F-RBC bismuth) nanoparticles in X-ray radiation therapy for breast cancer, where cell membrane coating provides long blood circulation time, folate acts as tumor targeting agent, X-ray and bismuth nanoparticles interaction generates more free radicals for cancer cells damage, and physiological condition helps dissolve bismuth nanoparticles after treatment. Significant tumor inhibition and improved survival ratio in mice was confirmed when F-RBC bismuth nanoparticles were used to sensitize X-ray radiation. In vivo bio-distribution and histological analysis indicated F-RBC bismuth nanoparticles were excreted from animal body after 15 days and no evident damage or inflammatory was observed in major organs. Cell membrane modification and dissolution of bismuth nanoparticles in body allow the fine tune of the circulation, radiation enhancement and body clearance in such a way that treatment effect can be maximized and long term toxicity can be minimized. (c) 2017 Elsevier Ltd. All rights reserved.