Effect of diabetes on renal medullary oxygenation during water diuresis
Effect of diabetes on renal medullary oxygenation during water diuresis
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DOI：
10.2337/diacare.25.3.575
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发表时间：
2002-03-01
期刊：
影响因子：
16.2
通讯作者：
Prasad, PV
中科院分区：
文献类型：
--
作者：
Epstein, FH;Veves, A;Prasad, PV
目的-使用血氧水平依赖性磁共振成像研究水利尿对糖尿病患者肾髓质和皮质氧合的影响研究设计和方法-九名轻度糖尿病受试者（48 ± 2.7岁，6名女性）和9名年龄和性别相似的非糖尿病受试者，均无已知的血管或肾脏疾病，结果：在对照组中，水利尿引起延髓氧合增加，产生R-2* 减少，（表观自旋-自旋弛豫时间）为1.89 +/- 0.27结论：在中年糖尿病患者中，与先前在>65岁的老年受试者中描述的相似，提示糖尿病肾髓质内适应性血管舒张的早期损害。
OBJECTIVE- To study the effect of water diuresis on renal medullary and cortical oxygenation in patients with diabetes using blood oxygenation level-dependent magnetic resonance imaging (BOLD MRI).RESEARCH DESIGN AND METHODS- Nine mild diabetic subjects (48 +/- 2.7 years of age, six women) and nine nondiabetic subjects of similar age and sex, all without known vascular or renal disease, were studied noninvasively by MRI before and during water diuresis.RESULTS- Water diuresis induced an increase in medullary oxygenation in control subjects, producing a decrease in R-2* (apparent spin-spin relaxation time) of 1.89 +/- 0.27 (P < 0.01), but no significant change in the group of diabetic subjects.CONCLUSIONS- These findings in middle-aged diabetic subjects, which resembled those previously described in elderly subjects >65 years of age, suggest early impairment of adaptive vasodilatation within the renal medulla in diabetes.