Intake, fecal excretion, and body burden of polychlorinated dibenzo-p-dioxins and dibenzofurans in breast-fed and formula-fed infants
Intake, fecal excretion, and body burden of polychlorinated dibenzo-p-dioxins and dibenzofurans in breast-fed and formula-fed infants
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DOI：
10.1203/00006450-199611000-00005
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发表时间：
1996-11-01
影响因子：
3.6
通讯作者：
Helge, H
中科院分区：
文献类型：
--
作者：
Abraham, K;Knoll, A;Helge, H
为评价多氯二苯并对二恶英（PCDDs）和二苯并呋喃（PCDFs）的毒性，对2名母乳喂养婴儿和1名配方奶粉喂养婴儿进行了出生后经口摄入和粪便排泄的测定。这些化合物的摄入量在母乳喂养的婴儿中高达50倍。在这些儿童中，主要的四氯至六氯同系物在1个月和5个月时的粪便排泄量不到摄入量的9%，表明母乳喂养期间几乎完全被肠道吸收。尽管断奶后多氯二苯并对二恶英/多氯二苯并呋喃的摄入量大大降低，但粪便脂肪中的浓度并未大幅降低。我们得出结论，粪便脂肪中的浓度或多或少反映了体脂中的浓度。此外，在11个月大的时候，测量了所有婴儿（以及第二个配方奶粉喂养的婴儿）的血脂中的多氯二苯并对二恶英/多氯二苯并呋喃浓度。配方奶粉喂养的婴儿的国际毒性当量（I-TEq）浓度低于母体值的25%，比母乳喂养6-7个月的婴儿低约10倍。在后者中，与母体浓度相比，发现四氯至六氯同系物有明显的累积。我们的结论是，多氯二苯并对二恶英和多氯二苯并呋喃在婴儿体内的积累与基于摄入量数据的预期一样高，并假设在生命的第一年中完全吸收和可忽略的消除。
To assess toxicokinetics of polychlorinated dibenzo;p-dioxins (PCDDs) and dibenzofurans (PCDFs), oral intake and fecal excretion were measured in two breast-fed infants and one formula-fed infant during the Ist y of life. The intake of these compounds was up to 50 times higher in the breast-fed infants. In these children, fecal excretion of the main tetra- to hexachlorinated congeners was less than 9% of the intake at age of 1 and 5 mo, indicating almost complete intestinal absorption during breast-feeding, In contrast, distinctly higher fecal excretion rates were observed for the hepta- and octachlorinated compounds. Despite much lower PCDD/PCDF intake after weaning, concentrations in stool fat did not decrease substantially. We conclude that concentrations in fecal fat more or less reflect those in body fat. Additionally, PCDD/PCDF concentrations were measured in blood fat of all infants (and in a second formula-fed baby) at the age of 11 mo. International toxicity equivalent (I-TEq) concentrations in the formula-fed infants were less than 25% of maternal values and about 10 times lower than in the infants breast-fed for 6-7 mo. In the latter, a distinct accumulation was found for the tetra- to hexachlorinated congeners compared with maternal concentrations. We conclude that accumulation of PCDDs and PCDFs in infants is as high as expected on the basis of intake data and assuming complete absorption and negligible elimination during the Ist y of life.